Designed construction of tween 60@2 beta-CD self-assembly vesicles as drug delivery carrier for cancer chemotherapy

doi:10.1080/10717544.2018.1440448

CORC > 化学研究所 > 中国科学院化学研究所

	Designed construction of tween 60@2 beta-CD self-assembly vesicles as drug delivery carrier for cancer chemotherapy
	Yuan, Yue 1; Zhang, Qin 1; Yan, Yun 2; Gong, Miaomiao 1; Zhao, Qi 1; Bao, Zhihong 1; Liu, Kaerdun 2; Wang, Siling 1
刊名	DRUG DELIVERY
	2018
卷号	25 期号:1 页码:623-631
关键词	Self-assembly Vesicles Dox Encapsulation Efficiency Cellular Uptake
ISSN号	1071-7544
DOI	10.1080/10717544.2018.1440448
英文摘要	We report a simple strategy to prepare Tween 60@2 beta-CD self-assembly vesicles in aqueous solution as a new drug delivery carrier for cancer chemotherapy. The spherical shape of vesicles was confirmed by transmission electron microscopy (TEM) and mean particle sizes were about 33.7 nm, as measured by dynamic light scattering, micro-IR results indicated that the self-assembly vesicles was driven by hydrogen bonding. Hydrophilic doxorubicin (DOX) was successfully loaded into the self-assembly vesicles with drug loading content of 7.85% and loading efficiency of 42%. In addition, an in vitro cytotoxicity study and cellular uptake assays demonstrated that the DOX-loaded Tween 60@2 beta-CD vesicles markedly enhanced the cellular uptake and cytotoxicity of DOX toward the Hela cells. Furthermore, when used to evaluate the in vivo therapeutic efficacy in mice bearing the breast cell line (4T1), DOX-loaded vesicles exhibited superior inhibition of tumor growth compared with the DOX solutions.
语种	英语
出版者	TAYLOR & FRANCIS LTD
WOS记录号	WOS:000436211000001
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/42541]
专题	中国科学院化学研究所
通讯作者	Wang, Siling
作者单位	1.Shenyang Pharmaceut Univ, Sch Pharm, 103 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China 2.Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Yuan, Yue,Zhang, Qin,Yan, Yun,et al. Designed construction of tween 60@2 beta-CD self-assembly vesicles as drug delivery carrier for cancer chemotherapy[J]. DRUG DELIVERY,2018,25(1):623-631.
APA	Yuan, Yue.,Zhang, Qin.,Yan, Yun.,Gong, Miaomiao.,Zhao, Qi.,...&Wang, Siling.(2018).Designed construction of tween 60@2 beta-CD self-assembly vesicles as drug delivery carrier for cancer chemotherapy.DRUG DELIVERY,25(1),623-631.
MLA	Yuan, Yue,et al."Designed construction of tween 60@2 beta-CD self-assembly vesicles as drug delivery carrier for cancer chemotherapy".DRUG DELIVERY 25.1(2018):623-631.