Frosted Slides Decorated with Silica Nanowires for Detecting Circulating Tumor Cells from Prostate Cancer Patients

doi:10.1021/acsami.8b06072

CORC > 化学研究所 > 中国科学院化学研究所

	Frosted Slides Decorated with Silica Nanowires for Detecting Circulating Tumor Cells from Prostate Cancer Patients
	Cui, Haijun 1,2; Wang, Binshuai 4; Wang, Wenshuo 1,2; Hao, Yuwei 2,3; Liu, Chuanyong 2; Song, Kai 1; Zhang, Shudong 4; Wang, Shutao 1,2
刊名	ACS APPLIED MATERIALS & INTERFACES
	2018-06-13
卷号	10 期号:23 页码:19545-19553
关键词	Nanobiochip Circulating Tumor Cells Silica Nanowires Interfacial Growth Topographic Interaction
ISSN号	1944-8244
DOI	10.1021/acsami.8b06072
英文摘要	Developing low-cost and highly efficient nanobiochips are important for liquid biopsies, real-time monitoring, and precision medicine. By in situ growth of silica nanowires on a commercial frosted slide, we develop a biochip for effective circulating tumor cells (CTCs) detection after modifying epithelial cell adhesion molecule antibody (anti-EpCAM). The biochip shows the specificity and high capture efficiency of 85.4 +/- 8.3% for prostate cancer cell line (PC-3). The microsized frosted slides and silica nanowires allow enhanced efficiency in capture EpCAM positive cells by synergistic topographic interactions. And the capture efficiency of biochip increased with the increase of silica nanowires length on frosted slide. The biochip shows that micro/nanocomposite structures improve the capture efficiency of PC-3 more than 70% toward plain slide. Furthermore, the nanobiochip has been successfully applied to identify CTCs from whole blood specimens of prostate cancer patients. Thus, this frosted slide-based biochip may provide a cheap and effective way of clinical monitoring of CTCs.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000435525100027
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/42531]
专题	中国科学院化学研究所
通讯作者	Zhang, Shudong; Wang, Shutao
作者单位	1.Chinese Acad Sci, CAS Ctr Excellence Nanosci, Tech Inst Phys & Chem, CAS Key Lab Bioinspired Mat & Interfacial Sci, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Key Lab Green Printing, Beijing 100190, Peoples R China 4.Peking Univ, Hosp 3, Dept Urol, Beijing 100191, Peoples R China
推荐引用方式 GB/T 7714	Cui, Haijun,Wang, Binshuai,Wang, Wenshuo,et al. Frosted Slides Decorated with Silica Nanowires for Detecting Circulating Tumor Cells from Prostate Cancer Patients[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(23):19545-19553.
APA	Cui, Haijun.,Wang, Binshuai.,Wang, Wenshuo.,Hao, Yuwei.,Liu, Chuanyong.,...&Wang, Shutao.(2018).Frosted Slides Decorated with Silica Nanowires for Detecting Circulating Tumor Cells from Prostate Cancer Patients.ACS APPLIED MATERIALS & INTERFACES,10(23),19545-19553.
MLA	Cui, Haijun,et al."Frosted Slides Decorated with Silica Nanowires for Detecting Circulating Tumor Cells from Prostate Cancer Patients".ACS APPLIED MATERIALS & INTERFACES 10.23(2018):19545-19553.