Simple D-A-D Structural Bisbithiophenyl Diketopyrrolopyrrole as Efficient Bioimaging and Photothermal Agents

doi:10.1021/acs.bioconjchem.8b00333

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	Simple D-A-D Structural Bisbithiophenyl Diketopyrrolopyrrole as Efficient Bioimaging and Photothermal Agents
	Zong, Shan 1; Wang, Xin 2; Lin, Wenhai 3,4; Liu, Shi 3,4; Zhang, Wei 3,4
刊名	BIOCONJUGATE CHEMISTRY
	2018-08-01
卷号	29 期号:8 页码:2619-2627
ISSN号	1043-1802
DOI	10.1021/acs.bioconjchem.8b00333
英文摘要	Design and synthesis of biocompatible and multifunctional photothermal agents is crucial for effective cancer phototherapy. In order to achieve this ambition, simple D-A-D structural bisbithiophenyl diketopyrrolopyrrole (TDPP) was fabricated. In this molecule, the donor, 2-thiophenylboric acid, was conjugated via Suzuki coupling reaction, which could expand the emission wavelength to the red region of the spectrum. TDPP could self-assemble into stable and uniform nano-particles (TDPP NPs) in assistant of amphiphilic Pluronic F-127 polymer. Exposing TDPP NPs (100 mu g/mL) aqueous dispersion to 638 nm (0.61 W/cm(2)) laser irradiation resulted in a temperature elevation of approximately 30 degrees C within 5 min, which is high enough for inducing the cytotoxicity and tumor inhibition. Because of the bathochromic shift absorption of TDPP NPs in water, TDPP NPs could also act as a contrast agent for near-infrared fluorescence imaging (NIRF) to visualize the drug distribution in vivo. Coupled with the infrared thermal imaging properties of the photothermal agent, TDPP NPs were proven to be a multifunctional theranostic agent for dual-modal imaging-guided phototherapy.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000442185500013
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/42407]
专题	中国科学院化学研究所
通讯作者	Liu, Shi; Zhang, Wei
作者单位	1.Jilin Univ, Hosp 1, Dept Gynecol Oncol, Changchun 130021, Jilin, Peoples R China 2.Jilin Univ, Hosp 1, Dept Thyroid Surg, 71 Xinmin St, Changchun 130021, Jilin, Peoples R China 3.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, 5625 Renmin St, Changchun 130022, Jilin, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zong, Shan,Wang, Xin,Lin, Wenhai,et al. Simple D-A-D Structural Bisbithiophenyl Diketopyrrolopyrrole as Efficient Bioimaging and Photothermal Agents[J]. BIOCONJUGATE CHEMISTRY,2018,29(8):2619-2627.
APA	Zong, Shan,Wang, Xin,Lin, Wenhai,Liu, Shi,&Zhang, Wei.(2018).Simple D-A-D Structural Bisbithiophenyl Diketopyrrolopyrrole as Efficient Bioimaging and Photothermal Agents.BIOCONJUGATE CHEMISTRY,29(8),2619-2627.
MLA	Zong, Shan,et al."Simple D-A-D Structural Bisbithiophenyl Diketopyrrolopyrrole as Efficient Bioimaging and Photothermal Agents".BIOCONJUGATE CHEMISTRY 29.8(2018):2619-2627.