Thermoresponsive Oligo(ethylene glycol)-Based Polymer Brushes on Polymer Monoliths for All-Aqueous Chromatography

doi:10.1021/am403510g

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	Thermoresponsive Oligo(ethylene glycol)-Based Polymer Brushes on Polymer Monoliths for All-Aqueous Chromatography
	Li, Nan 1,2; Qi, Li 1; Shen, Ying 1,2; Li, Yaping 1,2; Chen, Yi 1
刊名	ACS APPLIED MATERIALS & INTERFACES
	2013-12-11
卷号	5 期号:23 页码:12441-12448
关键词	Poly(2-(2-methoxyethoxy)Ethyl Methacrylate-co-oligo(Ethylene Glycol) Methacrylate) Brushes Two-step Atom Transfer Radical Polymerization Thermoresponsive Monolith Separation Hydrophobic Interaction
ISSN号	1944-8244
DOI	10.1021/am403510g
英文摘要	Porous polymer monoliths onto which were grafted a thermoresponsive copolymer, poly(2-(2-methoxyethoxy)ethyl methacrylate (MEO(2)MA)-co-oligo(ethylene glycol) methacrylate (OEGMA)), were synthesized by the two-step atom transfer radical polymerization (ATRP) method. The copolymer-grafted monoliths were characterized by elemental analysis, scanning electron microscopy, and mercury intrusion porosimetry. They were further used as the thermoresponsive stationary phase for all-aqueous high-performance liquid chromatography (HPLC). The chromatograms of three steroids demonstrated that the chain length of the grafted copolymer, which was regulated by varying the grafting time, could affect the separation by providing different amounts of hydrophobic interaction sites with analytes. Additionally, the elution profiles of steroids on the stationary phase could also be tuned by the comonomer composition. The results showed that the porous polymer monoliths enabled separation of the test mixture in pure aqueous mobile phase under isocratic conditions. Furthermore, the proposed method provides a simple and promising tool in the design and construction of responsive surfaces for chromatography applications.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000328439600031
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/41996]
专题	中国科学院化学研究所
通讯作者	Qi, Li
作者单位	1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Analyt Chem Living Biosyst, Inst Chem, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Li, Nan,Qi, Li,Shen, Ying,et al. Thermoresponsive Oligo(ethylene glycol)-Based Polymer Brushes on Polymer Monoliths for All-Aqueous Chromatography[J]. ACS APPLIED MATERIALS & INTERFACES,2013,5(23):12441-12448.
APA	Li, Nan,Qi, Li,Shen, Ying,Li, Yaping,&Chen, Yi.(2013).Thermoresponsive Oligo(ethylene glycol)-Based Polymer Brushes on Polymer Monoliths for All-Aqueous Chromatography.ACS APPLIED MATERIALS & INTERFACES,5(23),12441-12448.
MLA	Li, Nan,et al."Thermoresponsive Oligo(ethylene glycol)-Based Polymer Brushes on Polymer Monoliths for All-Aqueous Chromatography".ACS APPLIED MATERIALS & INTERFACES 5.23(2013):12441-12448.