A new aromatic glycoside and its anti-proliferative activities from the leaves of Bergenia purpurascens

	A new aromatic glycoside and its anti-proliferative activities from the leaves of Bergenia purpurascens
	Zhang, Shan-Shan ; Liao, Zhi-Xin ; Huang, Ri-Zhen ; Gong, Cheng-Cheng ; Ji, Lan-Ju ; Sun, Hong-Fa
刊名	NATURAL PRODUCT RESEARCH
	2018
英文摘要	Chemical investigation of the ethanolic extracts of the dried leaves of Bergenia purpurascens led to the isolation and identification of a new aromatic glycoside, 1-O-ss-D-glucopyranosyl-2-methoxy-3-hydroxylphenylethene( 1), along with other 19 known compounds (2-20). The structure of compound 1 was determined by a detailed analysis using various analytical techniques, including 1D and 2D NMR. In vitro anti- proliferative activities of compound 1 on five human cancer cell lines were evaluated. The results showed that compound 1 possessed the most potent effects with the IC50 values of 14.36 +/- 1.04 mu M against T24 cells. The further bioactivity analysis showed that compound 1 induced apoptosis of T24 cells, and altered anti- and pro-apoptotic proteins, leading to mitochondrial dysfunction and activation of caspase-3 for causing cell apoptosis. The present investigation illustrated compound 1 might be used as a potential antitumour chemotherapy candidate.
内容类型	期刊论文
源URL	[http://210.75.249.4/handle/363003/13343]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Zhang, Shan-Shan,Liao, Zhi-Xin,Huang, Ri-Zhen,et al. A new aromatic glycoside and its anti-proliferative activities from the leaves of Bergenia purpurascens[J]. NATURAL PRODUCT RESEARCH,2018.
APA	Zhang, Shan-Shan,Liao, Zhi-Xin,Huang, Ri-Zhen,Gong, Cheng-Cheng,Ji, Lan-Ju,&Sun, Hong-Fa.(2018).A new aromatic glycoside and its anti-proliferative activities from the leaves of Bergenia purpurascens.NATURAL PRODUCT RESEARCH.
MLA	Zhang, Shan-Shan,et al."A new aromatic glycoside and its anti-proliferative activities from the leaves of Bergenia purpurascens".NATURAL PRODUCT RESEARCH (2018).