Synthetic Catalysts Inspired by Hydrolytic Enzymes

doi:10.1021/acscatal.8b03326

	Synthetic Catalysts Inspired by Hydrolytic Enzymes
	Nothling, Mitchell D.1; Xiao, Zeyun2 ; Bhaskaran, Ayana 3; Blyth, Mitchell T.3; Bennet, Christopher W.3; Coote, Michelle L.3; Connal, Luke A.3
刊名	ACS CATALYSIS
	2019
卷号	9 期号:1 页码:168-187
关键词	hydrolytic enzyme enzyme mimic catalyst catalytic triad reaction mechanism
ISSN号	2155-5435
DOI	10.1021/acscatal.8b03326
通讯作者	Connal, Luke A.(luke.connal@anu.edu.au)
英文摘要	Enzymes, as nature's catalysts, speed up the very reactions that make life possible. Hydrolytic enzymes are a particularly important enzyme class responsible for the catalytic breakdown of lipids, starches, and proteins in nature, and they are displaying increasing industrial relevance. While the unrivalled catalytic effect of enzymes continues to be unmatched by synthetic systems, recent progress has been made in the design of hydrolase-inspired catalysts by imitating and incorporating specific features observed in native enzyme protein structures. The development of such enzyme-inspired materials holds promise for more robust and industrially relevant alternatives to enzymatic catalysis, as well as deeper insights into the function of native enzymes. This Review will explore recent research in the development of synthetic catalysts based on the chemistry of hydrolytic enzymes. A focus on the key aspects of hydrolytic enzyme structure and catalytic mechanism will be explored-including active-site chemistry, tuning transition-state interactions, and establishing reactive nanoenvironments conducive to attracting, binding, and releasing target molecules. A key focus is to highlight the progress toward an effective, versatile hydrolase-inspired catalyst by incorporating the molecular design principles laid down by nature.
资助项目	US Army International Technology Center Pacific[ITC-PAC FA5209-14-C-0017] ; Defense Science Institute ; Veski Innovation Fellowship ; John Stocker Postgraduate Scholarship ; Endeavour Research Fellowship ; Australian Nanotechnology Travelling Fellowship ; Australian Research Council Georgina Sweet Laureate Fellowship
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000455286600018
内容类型	期刊论文
源URL	[http://119.78.100.138/handle/2HOD01W0/7305]
专题	中国科学院重庆绿色智能技术研究院
通讯作者	Connal, Luke A.
作者单位	1.Univ Melbourne, Dept Chem & Biomol Engn, Parkville, Vic 3010, Australia 2.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China 3.Australian Natl Univ, Res Sch Chem, Canberra, ACT 2601, Australia
推荐引用方式 GB/T 7714	Nothling, Mitchell D.,Xiao, Zeyun,Bhaskaran, Ayana,et al. Synthetic Catalysts Inspired by Hydrolytic Enzymes[J]. ACS CATALYSIS,2019,9(1):168-187.
APA	Nothling, Mitchell D..,Xiao, Zeyun.,Bhaskaran, Ayana.,Blyth, Mitchell T..,Bennet, Christopher W..,...&Connal, Luke A..(2019).Synthetic Catalysts Inspired by Hydrolytic Enzymes.ACS CATALYSIS,9(1),168-187.
MLA	Nothling, Mitchell D.,et al."Synthetic Catalysts Inspired by Hydrolytic Enzymes".ACS CATALYSIS 9.1(2019):168-187.