Conjugation of Inulin Improves Anti-Biofilm Activity of Chitosan

doi:10.3390/md16050151

	Conjugation of Inulin Improves Anti-Biofilm Activity of Chitosan
	Zhang, GQ; Liu, J; Li, RL; Jiao, SM; Feng, C; Wang, ZA; Du, YG; Zhang, Guiqiang; Liu, Jing; Li, Ruilian
刊名	MARINE DRUGS
	2018
卷号	16 期号:5
关键词	Staphylococcus aureus INFECTIONS biofilm DERIVATIVES chitosan CHITIN conjugation AGENT inulin MODE MICE
ISSN号	1660-3397
DOI	10.3390/md16050151
文献子类	Article
英文摘要	Bacteria biofilm helps bacteria prevent phagocytosis during infection and increase resistance to antibiotics. Staphylococcus aureus is a Gram-positive pathogenic bacterium and is tightly associated with biofilm-related infections, which have led to great threat to human health. Chitosan, the only cationic polysaccharide in nature, has been demonstrated to have antimicrobial and anti-biofilm activities, which, however, require a relative high dosage of chitosan. Moreover, poor water solubility further restricts its applications on anti-infection therapy. Inulins are a group of polysaccharides produced by many types of plants, and are widely used in processed foods. Compared to chitosan, inulin is very soluble in water and possesses a mild antibacterial activity against certain pathogenic bacteria. In order to develop an effective strategy to treat biofilm-related infections, we introduce a method by covalent conjugation of inulin to chitosan. The physicochemical characterization of the inulin-chitosan conjugate was assayed, and the anti-biofilm activity was evaluated against S. aureus biofilm. The results indicated that, as compared to chitosan, this novel polysaccharide-polysaccharide conjugate significantly enhanced activities against S. aureus either in a biofilm or planktonic state. Of note, the conjugate also showed a broad spectrum anti-biofilm activity on different bacteria strains and low cellular toxicity to mammalian cells. These results suggested that chitosan conjugation of inulin was a viable strategy for treatment against biofilm-related infections. This finding may further spread the application of natural polysaccharides on treatments of infectious disease.
WOS记录号	WOS:000435195100014
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/28418]
专题	中国科学院过程工程研究所
推荐引用方式 GB/T 7714	Zhang, GQ,Liu, J,Li, RL,et al. Conjugation of Inulin Improves Anti-Biofilm Activity of Chitosan[J]. MARINE DRUGS,2018,16(5).
APA	Zhang, GQ.,Liu, J.,Li, RL.,Jiao, SM.,Feng, C.,...&Du, Yuguang.(2018).Conjugation of Inulin Improves Anti-Biofilm Activity of Chitosan.MARINE DRUGS,16(5).
MLA	Zhang, GQ,et al."Conjugation of Inulin Improves Anti-Biofilm Activity of Chitosan".MARINE DRUGS 16.5(2018).