Fabrication of short peptide cages by interfacial self-assembly on CaCO3 templates | |
Feng, Lu1,2; Ren, Peng1,2; Hao, Linna1,3; Dong, Qianqian1,3; Li, Jieling1; Jian, Honglei1; Wang, Meiyue1,2; Li, Xin1,2; Wang, Anhe1; Bai, Shuo1 | |
刊名 | COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS |
2019-07-20 | |
卷号 | 573页码:22-29 |
关键词 | Caco3 Microparticles Short Peptide Cages Self-assembly Confined Space |
ISSN号 | 0927-7757 |
DOI | 10.1016/j.colsurfa.2019.04.048 |
英文摘要 | Short peptide cages have great potential applications in drug encapsulation and release because of excellent biocompatibility, biodegradability and multi-functionality originated from their abundant sequences. However, constructing short peptide cages are still a challenge, which is caused by the rapid kinetic and unlimited self-assembly behavior of short peptide in a macroscopical media. Herein, we developed smart procedures to produce short peptide cages, in which porous CaCO3 microparticles were used as enzyme (thermolysin) carriers and applied as catalyzers to promote the condensation reaction of Fmoc-Y and L-NH2 in confined space of water/n-hexane emulsion which limited the self-assembly behavior of Fmoc-YL-NH2 and allowed the peptide to just selfassemble on CaCO3 surface. Intact short peptide cages would be produced after the removing the templates. |
资助项目 | National Natural Science Foundation of China[21774132] ; National Natural Science Foundation of China[21,703,253] |
WOS关键词 | Rational Design ; In-vitro ; Therapy ; Nanoparticles ; Hydrogels ; Transition ; Emulsions ; Nanocages ; Vesicles ; Release |
WOS研究方向 | Chemistry |
语种 | 英语 |
出版者 | ELSEVIER SCIENCE BV |
WOS记录号 | WOS:000468418300004 |
资助机构 | National Natural Science Foundation of China |
内容类型 | 期刊论文 |
源URL | [http://ir.ipe.ac.cn/handle/122111/28135] |
专题 | 中国科学院过程工程研究所 |
通讯作者 | Wang, Anhe; Bai, Shuo |
作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Jiangnan Univ, Sch Biotechnol, Minist Educ, Key Lab Carbohydrate Chem & Biotechnol, Wuxi 214122, Peoples R China |
推荐引用方式 GB/T 7714 | Feng, Lu,Ren, Peng,Hao, Linna,et al. Fabrication of short peptide cages by interfacial self-assembly on CaCO3 templates[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2019,573:22-29. |
APA | Feng, Lu.,Ren, Peng.,Hao, Linna.,Dong, Qianqian.,Li, Jieling.,...&Bai, Shuo.(2019).Fabrication of short peptide cages by interfacial self-assembly on CaCO3 templates.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,573,22-29. |
MLA | Feng, Lu,et al."Fabrication of short peptide cages by interfacial self-assembly on CaCO3 templates".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 573(2019):22-29. |
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