Edge-group sparse PCA for network-guided high dimensional data analysis

doi:10.1093/bioinformatics/bty362

CORC > 数学与系统科学研究院 > 中国科学院数学与系统科学研究院 > 应用数学研究所

	Edge-group sparse PCA for network-guided high dimensional data analysis
	Min, Wenwen 1; Liu, Juan 1; Zhang, Shihua2,3,4
刊名	BIOINFORMATICS
	2018-10-15
卷号	34 期号:20 页码:3479-3487
ISSN号	1367-4803
DOI	10.1093/bioinformatics/bty362
英文摘要	Motivation: Principal component analysis (PCA) has been widely used to deal with high-dimensional gene expression data. In this study, we proposed an Edge-group Sparse PCA (ESPCA) model by incorporating the group structure from a prior gene network into the PCA framework for dimension reduction and feature interpretation. ESPCA enforces sparsity of principal component (PC) loadings through considering the connectivity of gene variables in the prior network. We developed an alternating iterative algorithm to solve ESPCA. The key of this algorithm is to solve a new k-edge sparse projection problem and a greedy strategy has been adapted to address it. Here we adopted ESPCA for analyzing multiple gene expression matrices simultaneously. By incorporating prior knowledge, our method can overcome the drawbacks of sparse PCA and capture some gene modules with better biological interpretations. Results: We evaluated the performance of ESPCA using a set of artificial datasets and two real biological datasets (including TCGA pan-cancer expression data and ENCODE expression data), and compared their performance with PCA and sparse PCA. The results showed that ESPCA could identify more biologically relevant genes, improve their biological interpretations and reveal distinct sample characteristics.
资助项目	National Natural Science Foundation of China[11661141019] ; National Natural Science Foundation of China[61621003] ; National Natural Science Foundation of China[61422309] ; National Natural Science Foundation of China[61379092] ; Strategic Priority Research Program of the Chinese Academy of Sciences (CAS)[XDB13040600] ; Key Research Program of the Chinese Academy of Sciences[KFZD-SW-219] ; National Key Research and Development Program of China[2017YFC0908405] ; CAS Frontier Science Research Key Project for Top Young Scientist[QYZDB-SSW-SYS008]
WOS研究方向	Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Computer Science ; Mathematical & Computational Biology ; Mathematics
语种	英语
出版者	OXFORD UNIV PRESS
WOS记录号	WOS:000448782100008
内容类型	期刊论文
源URL	[http://ir.amss.ac.cn/handle/2S8OKBNM/31658]
专题	应用数学研究所
通讯作者	Liu, Juan; Zhang, Shihua
作者单位	1.Wuhan Univ, Sch Comp Sci, Wuhan 430072, Hubei, Peoples R China 2.Chinese Acad Sci, Acad Math & Syst Sci, NCMIS, CEMS,RCSDS, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Sch Math Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Min, Wenwen,Liu, Juan,Zhang, Shihua. Edge-group sparse PCA for network-guided high dimensional data analysis[J]. BIOINFORMATICS,2018,34(20):3479-3487.
APA	Min, Wenwen,Liu, Juan,&Zhang, Shihua.(2018).Edge-group sparse PCA for network-guided high dimensional data analysis.BIOINFORMATICS,34(20),3479-3487.
MLA	Min, Wenwen,et al."Edge-group sparse PCA for network-guided high dimensional data analysis".BIOINFORMATICS 34.20(2018):3479-3487.