Cytotoxic arylalkenyl alpha,beta-unsaturated delta-lactones from Cryptocarya brachythyrsa | |
Fan, Yue; Liu, Yu; You, Yun-Xia; Rao, Li; Su, Yu; He, Qian; Hu, Feng; Li, Yizhou; Wei, Weili; Xu, You-Kai | |
刊名 | FITOTERAPIA |
2019 | |
卷号 | 136期号:x页码:- |
关键词 | STEREOSELECTIVE TOTAL-SYNTHESIS INHIBITORY-ACTIVITY ALPHA-PYRONE FLAVONOIDS LEAVES CHINENSIS ALKALOIDS D1 |
ISSN号 | 0367-326X |
DOI | 10.1016/j.fitote.2019.05.006 |
英文摘要 | Three new arylalkenyl alpha,beta-unsaturated delta-lactones, cryptobrachytones A-C (1-3), together with one known analogue kurzilactone (4), were isolated from the leaves and twigs of Cryptocarya brachythyrsa. Their structures were elucidated based on extensive spectroscopic data and electronic circular dichroism (ECD) analysis. All the isolates were evaluated in vitro for anti-proliferative activity against a panel of five human cancer cell lines and one human normal cell, respectively, and the results showed 1, 2 and 4 possessing significant selective cytotoxicity toward the human cancer cell lines with IC50 values from 5.41 to 15.43 mu M. This is the first study for C. brachythyrsa. |
学科主题 | Pharmacology & Pharmacy |
语种 | 英语 |
WOS记录号 | WOS:000474320500014 |
内容类型 | 期刊论文 |
源URL | [http://ir.xtbg.org.cn/handle/353005/11336] |
专题 | 西双版纳热带植物园_民族植物学研究组 |
作者单位 | 1.Chongqing Univ, Chongqing Key Lab Nat Prod Synth & Drug Res, Sch Pharmaceut Sci, Chongqing 401331, Peoples R China 2.Chongqing Univ, Chem Biol Res Ctr, Sch Pharmaceut Sci, Chongqing 401331, Peoples R China 3.Chinese Acad Sci, Key Lab Trop Plant Resource & Sustainable Use, Xishuangbanna Trop Bot Garden, Menglun 666303, Yunnan, Peoples R China 4.Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Liaoning, Peoples R China |
推荐引用方式 GB/T 7714 | Fan, Yue,Liu, Yu,You, Yun-Xia,et al. Cytotoxic arylalkenyl alpha,beta-unsaturated delta-lactones from Cryptocarya brachythyrsa[J]. FITOTERAPIA,2019,136(x):-. |
APA | Fan, Yue.,Liu, Yu.,You, Yun-Xia.,Rao, Li.,Su, Yu.,...&Zhang, Chuan-Rui.(2019).Cytotoxic arylalkenyl alpha,beta-unsaturated delta-lactones from Cryptocarya brachythyrsa.FITOTERAPIA,136(x),-. |
MLA | Fan, Yue,et al."Cytotoxic arylalkenyl alpha,beta-unsaturated delta-lactones from Cryptocarya brachythyrsa".FITOTERAPIA 136.x(2019):-. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论