Two spiroketal derivatives with an unprecedented amino group and their cytotoxicity evaluation from the endophytic fungus Pestalotiopsis flavidula | |
Rao, Li; You, Yun-Xia; Su, Yu; Liu, Yu; He, Qian; Fan, Yue; Hu, Feng; Xu, You-Kai; Zhang, Chuan-Rui | |
刊名 | FITOTERAPIA |
2019 | |
卷号 | 135期号:x页码:5-8 |
关键词 | DIELS-ALDER REACTION BIOACTIVE METABOLITES FUNGICOLOUS ISOLATE NATURAL-PRODUCTS BIOSYNTHESIS SESQUITERPENOIDS MALDOXIN SKELETON |
ISSN号 | 0367-326X |
DOI | 10.1016/j.fitote.2019.03.020 |
英文摘要 | Two new spiroketal derivatives with an unprecedented amino group, 2'-aminodechloromaldoxin (1) and 2'-aminodechlorogeodoxin (2), along with one known analogue dechloromaldoxin (3), were isolated from the plant endophytic fungus Pestalotiopsis flavidula. Their structures were elucidated on the basis of extensive spectroscopic analysis. The purification was cytotoxicity-guided which indicated the extract, fractions and compounds were evaluated in vitro for anti-proliferative activity against a panel of human cancer cell lines. The results showed compounds 1 and 2 with moderate cytotoxicity while 3 was inactive, which suggested -NH2 group might play a very important role for their cytotoxicity. This is the first study for P. flavidula and the first time to report the spiroketal derivatives as alkaloids from the Pestalotiopsis genus. |
学科主题 | Pharmacology & Pharmacy |
语种 | 英语 |
WOS记录号 | WOS:000470048000002 |
内容类型 | 期刊论文 |
源URL | [http://ir.xtbg.org.cn/handle/353005/11310] |
专题 | 西双版纳热带植物园_民族植物学研究组 |
作者单位 | 1.[Rao, Li 2.You, Yun-Xia 3.Su, Yu 4.Liu, Yu 5.He, Qian 6.Fan, Yue 7.Hu, Feng 8.Chongqing Univ, Chongqing Key Lab Nat Prod Synth & Drug Res, Sch Pharmaceut Sci, Chongqing 401331, Peoples R China 9.Chongqing Univ, Tumour Targeted Therapy & Chem Biol Res Ctr, Sch Pharmaceut Sci, Chongqing 401331, Peoples R China 10.Chinese Acad Sci, Key Lab Trop Plant Resource & Sustainable Use, Xishuangbanna Trop Bot Garden, Menglun 666303, Yunnan, Peoples R China |
推荐引用方式 GB/T 7714 | Rao, Li,You, Yun-Xia,Su, Yu,et al. Two spiroketal derivatives with an unprecedented amino group and their cytotoxicity evaluation from the endophytic fungus Pestalotiopsis flavidula[J]. FITOTERAPIA,2019,135(x):5-8. |
APA | Rao, Li.,You, Yun-Xia.,Su, Yu.,Liu, Yu.,He, Qian.,...&Zhang, Chuan-Rui.(2019).Two spiroketal derivatives with an unprecedented amino group and their cytotoxicity evaluation from the endophytic fungus Pestalotiopsis flavidula.FITOTERAPIA,135(x),5-8. |
MLA | Rao, Li,et al."Two spiroketal derivatives with an unprecedented amino group and their cytotoxicity evaluation from the endophytic fungus Pestalotiopsis flavidula".FITOTERAPIA 135.x(2019):5-8. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论