Triphenyl Phosphate (TPHP)-Induced Neurotoxicity in Adult Male Chinese Rare Minnows (Gobiocypris rarus)

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 中国科学院饮用水科学与技术重点实验室

	Triphenyl Phosphate (TPHP)-Induced Neurotoxicity in Adult Male Chinese Rare Minnows (Gobiocypris rarus)
	Zha, Jinmiao; Yuan, Lilai; Hou, Rui; Chen, Rui; Hong, Xiangsheng
刊名	ENVIRONMENTAL SCIENCE & TECHNOLOGY
	2018-10-16
卷号	52 期号:20 页码:11895-11903
ISSN号	0013-936X
文献子类	Article
英文摘要	The neurotoxicity of triphenyl phosphate (TPHP) in exposed humans and laboratory animals is under debate. The rapid crossing of the blood-brain barrier (BBB) and high distribution of TPHP in fish brains have raised widespread concerns about potential neurotoxicity. Adult male Chinese rare minnows (Gobiocypris rarus) were used as a model and exposed to 0, 20, or 100 mu g/L TPHP for 28 days. We evaluated the BBB permeability, neuroinflammatory response, cell proliferation and apoptosis, synaptic plasticity and synapse loss in fish brains via the learning/memory performance of fish following 28 days of TPHP exposure. TPHP significantly increased the BBB permeability, activated the neuroinflammatory response, and decreased the tight junction-related mRNA levels of claudin-5 alpha and occludin in the fish brain. In addition, cell proliferation was inhibited by treatment with 100 mu g/L TPHP, but no significant apoptosis was observed in the brain. Fish exposed to 100 mu g/L TPHP exhibited significantly decreased dendritic arborization in pyramidal neurons in the cerebellum (Ce), and the maze test indicated impaired learning/memory performance. Taken together, these findings provide scientific evidence that TPHP is neurotoxic to fish and further suggest that TPHP may not be a safe alternative for aquatic organisms.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/41431]
专题	生态环境研究中心_中国科学院饮用水科学与技术重点实验室
推荐引用方式 GB/T 7714	Zha, Jinmiao,Yuan, Lilai,Hou, Rui,et al. Triphenyl Phosphate (TPHP)-Induced Neurotoxicity in Adult Male Chinese Rare Minnows (Gobiocypris rarus)[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2018,52(20):11895-11903.
APA	Zha, Jinmiao,Yuan, Lilai,Hou, Rui,Chen, Rui,&Hong, Xiangsheng.(2018).Triphenyl Phosphate (TPHP)-Induced Neurotoxicity in Adult Male Chinese Rare Minnows (Gobiocypris rarus).ENVIRONMENTAL SCIENCE & TECHNOLOGY,52(20),11895-11903.
MLA	Zha, Jinmiao,et al."Triphenyl Phosphate (TPHP)-Induced Neurotoxicity in Adult Male Chinese Rare Minnows (Gobiocypris rarus)".ENVIRONMENTAL SCIENCE & TECHNOLOGY 52.20(2018):11895-11903.