Preliminary test on the distribution, hydrolyzation and excretion of aluminum dialkyl phosphinate flame retardants in rats

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Preliminary test on the distribution, hydrolyzation and excretion of aluminum dialkyl phosphinate flame retardants in rats
	Li, Lisha; Liu, Yuchen; Liu, Jiyan; Liu, Jingfu; Niu, Yumin; Liang, Yong
刊名	ENVIRONMENTAL POLLUTION
	2018-11-01
卷号	242 页码:1998-2004
关键词	Aluminum methylcyclohexyl phosphinic Distribution Excretion Hydrolysis
ISSN号	0269-7491
文献子类	Article
英文摘要	Aluminum dialkyl phosphinates (ADPs) are a promising class of chemicals offering superior flame retardance. However, knowledge on their behavior in vivo is scarce. Hydrolysis has been suggested as one of the major routes of environmental degradation of ADPs. Herein, aluminum methylcyclohexyl phosphinic (AMHP), a kind of ADPs with industrial production in China, and its hydrolysate methyl cyclohexyl phosphinic acid (MHPA) were continuously exposed to Sprague Dawley (SD) rats for 28 days in this study. The same ratio of MHPA in organs to serum and the same daily excretion of MHPA were observed for AMHP exposure group and MHPA exposure group, suggesting the hydrolysis of AMHP in vivo. The hydrolysis of AMHP to MHPA was further confirmed by in vitro simulated human gastric intestinal juice. Therefore, both AMHP and MHPA distributed in liver, kidney and even brain in the form of MHPA. More than 80% of AMHP and MHPA could be excreted by feces and urine. Feces are the main route of excretion of AMHP and MHPA. The denseness of the inflammatory cell in the hepatic portal area and biochemical indexes showed the obvious dose-effect relationship. However, the toxicity of AMHP and MHPA was quite low even with exposure level up to 100 mg/kg dw/day. The low cumulative ability and mild toxicity indicated AMHP as a promising substitute for brominated flame retardant. (C) 2018 Published by Elsevier Ltd.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/41016]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Li, Lisha,Liu, Yuchen,Liu, Jiyan,et al. Preliminary test on the distribution, hydrolyzation and excretion of aluminum dialkyl phosphinate flame retardants in rats[J]. ENVIRONMENTAL POLLUTION,2018,242:1998-2004.
APA	Li, Lisha,Liu, Yuchen,Liu, Jiyan,Liu, Jingfu,Niu, Yumin,&Liang, Yong.(2018).Preliminary test on the distribution, hydrolyzation and excretion of aluminum dialkyl phosphinate flame retardants in rats.ENVIRONMENTAL POLLUTION,242,1998-2004.
MLA	Li, Lisha,et al."Preliminary test on the distribution, hydrolyzation and excretion of aluminum dialkyl phosphinate flame retardants in rats".ENVIRONMENTAL POLLUTION 242(2018):1998-2004.