Preliminary investigation on cytotoxicity of fluorinated polymer nanoparticles

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Preliminary investigation on cytotoxicity of fluorinated polymer nanoparticles
	Wang, Xue; Cheng, Wenge; Yang, Qiuyuan; Niu, Hongyun; Liu, Qian; Liu, Yun; Gao, Ming; Xu, Ming; Xu, An; Liu, Sijin
刊名	JOURNAL OF ENVIRONMENTAL SCIENCES
	2018-07-01
卷号	69 页码:217-226
关键词	Fluorinated nanoparticles Polymer Cytotoxicity Oxidative stress Health risk
ISSN号	1001-0742
文献子类	Article
英文摘要	As well-known persistent organic pollutants (POPs), organofluorine pollutants such as perfluorooctane sulfonate (PFOS) have been proven to be bioaccumulated and harmful to health. However, toxicological assessment of organofluorinated nanoparticles, which have emerged as a novel tool for biomedical and industrial applications, is lacking, to the best of our knowledge. To assess the biological effects and health risk of fluorinated nanoparticles, trifluoroethyl aryl ether-based fluorinated poly(methyl methacrylate) nanoparticles (PTFE-PMMA NPs) were synthesized with various fluorine contents (PTFE-PMMA-1 NPs 12.0 wt.%, PTFE-PMMA-2 NPs 6.1 wt.% and PTFE-PMMA-3 NPs 5.0 wt.%), and their cytotoxicity was investigated in this study. The in vitro experimental results indicated that the cytotoxicity of PTFE-PMMA NPs was mild, and was closely related to their fluorine (F) contents and F-containing side chains. Specifically, the cytotoxicity of PTFE-PMMA NPs decreased with increasing F content and F-containing side chains. After exposure to PTFE-PMMA NPs at a sublethal dose (50 mu g/mL) for 24 hr, the phospholipid bilayer was damaged, accompanied by increasing permeability of the cell membrane. Meanwhile, the intracellular accumulation of reactive oxygen species (ROS) occurred, resulting in the increase of DNA damage, cell cycle arrest and cell death. Overall, the PTFE-PMMA NPs were found to be relatively safe compared with typical engineered nanomaterials (ENMs), such as silver nanoparticles and graphene oxide, for biomedical and industrial applications. (c) 2017 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/41015]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Wang, Xue,Cheng, Wenge,Yang, Qiuyuan,et al. Preliminary investigation on cytotoxicity of fluorinated polymer nanoparticles[J]. JOURNAL OF ENVIRONMENTAL SCIENCES,2018,69:217-226.
APA	Wang, Xue.,Cheng, Wenge.,Yang, Qiuyuan.,Niu, Hongyun.,Liu, Qian.,...&Du, Yuguo.(2018).Preliminary investigation on cytotoxicity of fluorinated polymer nanoparticles.JOURNAL OF ENVIRONMENTAL SCIENCES,69,217-226.
MLA	Wang, Xue,et al."Preliminary investigation on cytotoxicity of fluorinated polymer nanoparticles".JOURNAL OF ENVIRONMENTAL SCIENCES 69(2018):217-226.