Mass Fractions, Congener Group Patterns, and Placental Transfer of Short- and Medium-Chain Chlorinated Paraffins in Paired Maternal and Cord Serum

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Mass Fractions, Congener Group Patterns, and Placental Transfer of Short- and Medium-Chain Chlorinated Paraffins in Paired Maternal and Cord Serum
	Zheng, Minghui; Qiao, Lin; Gao, Lirong; Wang, Runhua; Cui, Lili; Xu, Chi; Xia, Dan; Li, Jingguang; Zhang, Lei; Wu, Yongning
刊名	ENVIRONMENTAL SCIENCE & TECHNOLOGY
	2018-09-04
卷号	52 期号:17 页码:10097-10103
ISSN号	0013-936X
文献子类	Article
英文摘要	Multiple studies have demonstrated the occurrences of short-chain chlorinated paraffins (SCCPs) and medium-chain chlorinated paraffins (MCCPs) in environmental matrixes, but human internal exposure to them has been studied rarely. Mass fractions and congener group patterns of SCCPs and MCCPs in paired maternal and cord serum were studied for the first time to investigate the placental transport mechanism and prenatal exposure risks of CPs. Samples were collected in Beijing, China, and analyzed using two-dimensional gas chromatography coupled to time of-flight mass spectrometry. SCCP and MCCP mass fractions in maternal serum were 21.7-373 and 3.76-31.8 ng/g ww, respectively. They were 8.51-107 and 1.33-12.9 ng/g ww, respectively, in cord serum. Significant positive correlation between SCCP and MCCP levels in maternal serum was found (p < 0.01), suggesting SCCPs and MCCPs may undergo similar accumulation, transfer, and transformation pathways. The predominant congener groups for SCCP and MCCP in maternal serum were C10-11C16-7 and C14Cl7-8. The homologue profiles of CPs in cord serum were similar but with varied contribution percentage compared with those in maternal serum. By calculating and comparing cord-maternal serum ratios for each individual congener group, passive diffusion was recognized to be the possible placental transport form. The relationships between CP and thyroid hormone concentrations (THs) indicated that exposure to CPs might affect circulating TSHs. C-9-CPs were also detected, improving our understanding of CPs in human serum.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/40979]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Zheng, Minghui,Qiao, Lin,Gao, Lirong,et al. Mass Fractions, Congener Group Patterns, and Placental Transfer of Short- and Medium-Chain Chlorinated Paraffins in Paired Maternal and Cord Serum[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2018,52(17):10097-10103.
APA	Zheng, Minghui.,Qiao, Lin.,Gao, Lirong.,Wang, Runhua.,Cui, Lili.,...&Wu, Yongning.(2018).Mass Fractions, Congener Group Patterns, and Placental Transfer of Short- and Medium-Chain Chlorinated Paraffins in Paired Maternal and Cord Serum.ENVIRONMENTAL SCIENCE & TECHNOLOGY,52(17),10097-10103.
MLA	Zheng, Minghui,et al."Mass Fractions, Congener Group Patterns, and Placental Transfer of Short- and Medium-Chain Chlorinated Paraffins in Paired Maternal and Cord Serum".ENVIRONMENTAL SCIENCE & TECHNOLOGY 52.17(2018):10097-10103.