Highly Erbium-Doped Nanoplatform with Enhanced Red Emission for Dual-Modal Optical-Imaging-Guided Photodynamic Therapy

doi:10.1021/acs.inorgchem.8b02257

	Highly Erbium-Doped Nanoplatform with Enhanced Red Emission for Dual-Modal Optical-Imaging-Guided Photodynamic Therapy
	Feng, Miao 1; Lv, Ruichan 1; Xiao, Liyang 1; Hu, Bo 1; Zhu, Shouping 1; He, Fei 2; Yang, Piaoping 2; Tian, Jie1,3
刊名	INORGANIC CHEMISTRY
	2018-12-03
卷号	57 期号:23 页码:14594-14602
ISSN号	0020-1669
DOI	10.1021/acs.inorgchem.8b02257
通讯作者	Lv, Ruichan(rclv@xidian.edu.cn) ; Yang, Piaoping(yangpiaoping@hrbeu.edu.cn) ; Tian, Jie(jie.tian@ia.ac.cn)
英文摘要	Generally, luminescence quenching at high doping concentrations typically limits the concentration of doped ions in the lanthanide material to less than 0.05-20 mol %, and this is still a major hindrance in designing nanoplatforms with improved brightness. In this research, a nanoplatform capable of dual-modal imaging and synergetic antitumor cells therapy was designed. NaYF4:x%Er@NaXF4 (x = 5, 25, 50, and 100; X = Lu and Y) core@shell nanoparticles with Er3+ ion concentration up to 100 mol % were synthesized, and the luminescence properties under near-infrared (NIR) excitation were detected. The results show the strong coupled of surface and concentration quenching effects in upconversion nanoparticles (UCNP). Upconversion luminescence (UCL) and NIR-II emission intensity increased with negligible concentration quenching effect under 980 and 800 nm NIR lasers because of the growth of epitaxial shells. Therefore, the enhanced red luminescence transfers energy to photosensitizer ZnPc as the photodynamic therapy (PDT) agent for tumor inhibition efficacy.
资助项目	Natural Science Foundation of China[NSFC 81227901] ; Natural Science Foundation of China[81772011] ; Natural Science Foundation of China[81801744] ; National Key R&D Program of China[2016YFC0102000] ; National Key R&D Program of China[2017YFA0205202] ; National Key R&D Program of China[2017YFA0205200] ; Fundamental Research Funds for the Central Universities[XJS17011] ; Fundamental Research Funds for the Central Universities[JBX181202]
WOS关键词	UP-CONVERSION NANOPARTICLES ; ENERGY-TRANSFER ; LIGHT ; SHELL ; NANOCRYSTALS ; LUMINESCENCE ; SURFACE ; DESIGN ; NANOPHOSPHOR ; STRATEGY
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000452344400019
资助机构	Natural Science Foundation of China ; National Key R&D Program of China ; Fundamental Research Funds for the Central Universities
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/25669]
专题	中国科学院自动化研究所
通讯作者	Lv, Ruichan; Yang, Piaoping; Tian, Jie
作者单位	1.Xidian Univ, Sch Life Sci & Technol, Engn Res Ctr Mol & Neuro Imaging, Minist Educ, Xian 710071, Shaanxi, Peoples R China 2.Harbin Engn Univ, Coll Mat Sci & Chem Engn, Key Lab Superlight Mat & Surface Technol, Minist Educ, Harbin 150001, Heilongjiang, Peoples R China 3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Feng, Miao,Lv, Ruichan,Xiao, Liyang,et al. Highly Erbium-Doped Nanoplatform with Enhanced Red Emission for Dual-Modal Optical-Imaging-Guided Photodynamic Therapy[J]. INORGANIC CHEMISTRY,2018,57(23):14594-14602.
APA	Feng, Miao.,Lv, Ruichan.,Xiao, Liyang.,Hu, Bo.,Zhu, Shouping.,...&Tian, Jie.(2018).Highly Erbium-Doped Nanoplatform with Enhanced Red Emission for Dual-Modal Optical-Imaging-Guided Photodynamic Therapy.INORGANIC CHEMISTRY,57(23),14594-14602.
MLA	Feng, Miao,et al."Highly Erbium-Doped Nanoplatform with Enhanced Red Emission for Dual-Modal Optical-Imaging-Guided Photodynamic Therapy".INORGANIC CHEMISTRY 57.23(2018):14594-14602.