Hypoxia-active nanoparticles used in tumor theranostic

doi:10.2147/IJN.S196959

	Hypoxia-active nanoparticles used in tumor theranostic
	Wang, Yaqin 1,2; Shang, Wenting 2; Niu, Meng 1; Tian, Jie2,3 ; Xu, Ke 1
刊名	INTERNATIONAL JOURNAL OF NANOMEDICINE
	2019
卷号	14 页码:3705-3722
关键词	prodrug tumor microenvironment metal complex bioreductive
ISSN号	1178-2013
DOI	10.2147/IJN.S196959
通讯作者	Tian, Jie(jie.tian@ia.ac.cn) ; Xu, Ke(kexu@sina.vip.com)
英文摘要	Hypoxia is a hallmark of malignant tumors and often correlates with increasing tumor aggressiveness and poor treatment outcomes. Therefore, early diagnosis and effective killing of hypoxic tumor cells are crucial for successful tumor control. There has been a surge of interdisciplinary research aimed at developing functional molecules and nanomaterials that can be used to noninvasively image and efficiently treat hypoxic tumors. These mainly include hypoxia-active nanoparticles, anti-hypoxia agents, and agents that target biomarkers of tumor hypoxia. Hypoxia-active nanoparticles have been intensively investigated and have demonstrated advanced effects on targeting tumor hypoxia. In this review, we present an overview of the reports published to date on hypoxia-activated prodrugs and their nanoparticle forms used in tumor-targeted therapy. Hypoxia-responsive nanoparticles are inactive during blood circulation and normal physiological conditions but are activated by hypoxia once they extravasate into the hypoxic tumor microenvironment. Their use can enhance the efficiency of tumor chemotherapy, radiotherapy, fluorescence and photoacoustic intensity, and other imaging and therapeutic strategies. By targeting the broad habitats of tumors, rather than tumor-specific receptors, this strategy has the potential to overcome the problem of tumor heterogeneity and could be used to design diagnostic and therapeutic nanoparticles for a broad range of solid tumors.
资助项目	National Key R&D Program of China[2017YFA0700401] ; National Key R&D Program of China[2017YFA0205200] ; National Key R&D Program of China[2018YFC0115500] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81501540] ; National Natural Science Foundation of China[61231004] ; National Natural Science Foundation of China[81630053]
WOS关键词	CONJUGATED POLYMER DOTS ; CARBONIC-ANHYDRASE IX ; IN-VIVO ; MITOMYCIN-C ; BIOREDUCTIVE COMPOUND ; ANTICANCER PRODRUGS ; SELECTIVE TOXICITY ; TARGETING HYPOXIA ; CELL CARCINOMA ; DRUG-DELIVERY
WOS研究方向	Science & Technology - Other Topics ; Pharmacology & Pharmacy
语种	英语
出版者	DOVE MEDICAL PRESS LTD
WOS记录号	WOS:000469112600001
资助机构	National Key R&D Program of China ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/24408]
专题	中国科学院自动化研究所
通讯作者	Tian, Jie; Xu, Ke
作者单位	1.China Med Univ, Affiliated Hosp 1, Dept Intervent Radiol, 155 Nanjing North St, Shenyang 110000, Liaoning, Peoples R China 2.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China 3.Beihang Univ, Inst Med Interdisciplinary Innovat, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yaqin,Shang, Wenting,Niu, Meng,et al. Hypoxia-active nanoparticles used in tumor theranostic[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2019,14:3705-3722.
APA	Wang, Yaqin,Shang, Wenting,Niu, Meng,Tian, Jie,&Xu, Ke.(2019).Hypoxia-active nanoparticles used in tumor theranostic.INTERNATIONAL JOURNAL OF NANOMEDICINE,14,3705-3722.
MLA	Wang, Yaqin,et al."Hypoxia-active nanoparticles used in tumor theranostic".INTERNATIONAL JOURNAL OF NANOMEDICINE 14(2019):3705-3722.