Metastasis is the leading cause of breast cancer-related death. Chemokine (C-C motif) receptor 7(CCR7) plays important roles in breast cancer metastasis. However, the role of CCR7 in triple-negative breast cancer (TNBC) has not been fully elucidated. In this study, we found that CCR7 ishighly expressed in both TNBC cell lines and breast cancer tissues. CCR7 was knocked down byshRNA in 4T1 and MDA-MB-231, two TNBC cell lines, and we found that the depletion of CCR7 sig-nificantly decreased TNBC cell proliferation, migration and invasion in vitro. Furthermore, we con-firmed that the knockdown of CCR7 reduced the distant metastasis of 4T1 cells in an orthotopicmouse model. Proteomic analysis in 4T1 cells indicated that several signaling pathways such asepithelial cell adhesion molecule might contribute to CCR7’s function in breast cancer metastasis.Our results suggest that CCR7 promotes TNBC metastasis and may serve as a target for breastcancer diagnosis and treatment.