Neural substrates underlying the effects of oxytocin: a quantitative meta-analysis of pharmaco-imaging studies

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室

	Neural substrates underlying the effects of oxytocin: a quantitative meta-analysis of pharmaco-imaging studies
	Yan XY 2; yma@bnu.edu.cn ; Ma YN*2; Li M 1; Wang DY 2
刊名	Social Cognitive and Affective Neuroscience
	2017
卷号	12 期号:10 页码:1565–1573
关键词	Amygdala Fmri Meta-analysis Oxytocin Social Adaptation
英文摘要	The hypothalamic peptide oxytocin (OT) is crucial in social adaptation and used to treat emotional and social deficits. Here, we conducted a systematic, quantitative meta-analysis of functional-MRI studies intranasally administering OT (IN-OT) to uncover neural substrates underlying the IN-OT effects and to elucidate differential IN-OT effects between healthy and clinical populations. Meta-analyses were conducted on 66 IN-OT fMRI studies, stratified by psychopathology, valence and sex. IN-OT increased bilateral amygdala, caudate head, and superior temporal activity in healthy individuals and increased dorsal anterior cingulate activity in patients. Moreover, IN-OT decreased amygdala activity in both patients and healthy individuals but did so to a greater degree in patients than healthy individuals. The OT-increased amygdala activity was only found on the negative social and affective processes, whereas the OT-decreased amygdala activity was mainly contributed by contrasts on negative-valenced processes. IN-OT increased parahippocampal activity and decreased amygdala activity during negative socio-affective processing. During positive socio-affective processes, IN-OT increased caudate head activity. This study indicates convergent neural substrates and the underlying neuropsychological mechanisms for IN-OT effects on social and affective processes. The common and different effects of IN-OT on patients and healthy individuals and the modulation of OT effects by valence have critical implications.
语种	英语
资助机构	This work was supported by the National Natural Science Foundation of China (91632118); startup funding from the State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University; Open Research Fund of the State Key Laboratory of Cognitive Neuroscience, Beijing Normal University; the Fundamental Research Funds for the Central Universities; and Beijing Municipal Science & Technology Commission (Z151100003915122). ; This work was supported by the National Natural Science Foundation of China (91632118); startup funding from the State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University; Open Research Fund of the State Key Laboratory of Cognitive Neuroscience, Beijing Normal University; the Fundamental Research Funds for the Central Universities; and Beijing Municipal Science & Technology Commission (Z151100003915122). ; This work was supported by the National Natural Science Foundation of China (91632118); startup funding from the State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University; Open Research Fund of the State Key Laboratory of Cognitive Neuroscience, Beijing Normal University; the Fundamental Research Funds for the Central Universities; and Beijing Municipal Science & Technology Commission (Z151100003915122). ; This work was supported by the National Natural Science Foundation of China (91632118); startup funding from the State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University; Open Research Fund of the State Key Laboratory of Cognitive Neuroscience, Beijing Normal University; the Fundamental Research Funds for the Central Universities; and Beijing Municipal Science & Technology Commission (Z151100003915122).
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/12083]
专题	昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_转化基因组
通讯作者	yma@bnu.edu.cn
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China. 2.State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China.
推荐引用方式 GB/T 7714	Yan XY,yma@bnu.edu.cn,Ma YN*,et al. Neural substrates underlying the effects of oxytocin: a quantitative meta-analysis of pharmaco-imaging studies[J]. Social Cognitive and Affective Neuroscience,2017,12(10):1565–1573.
APA	Yan XY,yma@bnu.edu.cn,Ma YN*,Li M,&Wang DY.(2017).Neural substrates underlying the effects of oxytocin: a quantitative meta-analysis of pharmaco-imaging studies.Social Cognitive and Affective Neuroscience,12(10),1565–1573.
MLA	Yan XY,et al."Neural substrates underlying the effects of oxytocin: a quantitative meta-analysis of pharmaco-imaging studies".Social Cognitive and Affective Neuroscience 12.10(2017):1565–1573.