Indole Alkaloids Inhibiting Neural Stem Cell from Uncaria rhynchophylla

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	Indole Alkaloids Inhibiting Neural Stem Cell from Uncaria rhynchophylla
	Wei X 1,7; Guo Y 1,7; Chen YB 6; Wang YF5; Luo XD3,4; Khan A 2; Zhao YL 1; wangyifen@mail.kib.ac.cn ; Liu YP 1; Wang B 1,7
刊名	Nat. Prod. Bioprospect.
	2017
卷号	期号:页码:published online
关键词	Indole Alkaloids Nscs Proliferation Uncaria Rhynchophylla
英文摘要	Uncaria rhynchophylla is commonly recognized as a traditional treatment for dizziness, cerebrovascular diseases, and nervous disorders in China. Previously, the neuro-protective activities of the alkaloids from U. rhynchophylla were intensively reported. In current work, three new indole alkaloids (1-3), identified as geissoschizic acid (1), geissoschizic acid N 4-oxide (2), and 3β-sitsirikine N 4-oxide (3), as well as 26 known analogues were isolated from U. rhynchophylla. However, in the neural stem cells (NSCs) proliferation assay for all isolated compounds, geissoschizic acid (1), geissoschizic acid N 4-oxide (2), isocorynoxeine (6), isorhynchophylline (7), (4S)-akuammigine N-oxide (8), and (4S)-rhynchophylline N-oxide (10) showed unexpected inhibitory activities at 10 μM. Unlike previous neuro-protective reports, as a warning or caution, our finding showcased a clue for possible NSCs toxicity and the neural lesions risk of U. rhynchophylla, while the structure-activity relationships of the isolated compounds were discussed also.
语种	英语
资助机构	The authors are grateful to the National Natural Science Foundation of China (81225024, 31500292, 31770388) for financial support. ; The authors are grateful to the National Natural Science Foundation of China (81225024, 31500292, 31770388) for financial support. ; The authors are grateful to the National Natural Science Foundation of China (81225024, 31500292, 31770388) for financial support. ; The authors are grateful to the National Natural Science Foundation of China (81225024, 31500292, 31770388) for financial support.
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/12055]
专题	昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_肿瘤信号转导
通讯作者	wangyifen@mail.kib.ac.cn; xdluo@mail.kib.ac.cn
作者单位	1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of Chin 2.Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad, 22060, Pakistan 3.Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming, 650201, People's Republic of China 4.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China 5.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China 6.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, People's Republic of China 7.University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China
推荐引用方式 GB/T 7714	Wei X,Guo Y,Chen YB,et al. Indole Alkaloids Inhibiting Neural Stem Cell from Uncaria rhynchophylla[J]. Nat. Prod. Bioprospect.,2017,():published online.
APA	Wei X.,Guo Y.,Chen YB.,Wang YF.,Luo XD.,...&Jiang LP.(2017).Indole Alkaloids Inhibiting Neural Stem Cell from Uncaria rhynchophylla.Nat. Prod. Bioprospect.,(),published online.
MLA	Wei X,et al."Indole Alkaloids Inhibiting Neural Stem Cell from Uncaria rhynchophylla".Nat. Prod. Bioprospect. .(2017):published online.