In Vivo Biodistribution and Toxicity of Highly Soluble PEG-Coated Boron Nitride in Mice

doi:10.1186/s11671-015-1172-0

	In Vivo Biodistribution and Toxicity of Highly Soluble PEG-Coated Boron Nitride in Mice
	Liu, Bo 2; Qi, Wei 1; Tian, Longlong 2; Li, Zhan 3; Miao, Guoying 4; An, Wenzhen 5; Liu, Dan 2; Lin, Jing 2; Zhang, Xiaoyong 6; Wu, Wangsuo 2
刊名	NANOSCALE RESEARCH LETTERS
	2015-12-10
卷号	10
关键词	Biodistribution Toxicity Soluble Boron Nitride (Bn)
ISSN号	1556-276X
DOI	10.1186/s11671-015-1172-0
文献子类	Article
英文摘要	The boron nitride (BN) nanoparticles, as the structural analogues of graphene, are the potential biomedicine materials because of the excellent biocompatibility, but their solubility and biosafety are the biggest obstacle for the clinic application. Here, we first synthesized the highly soluble BN nanoparticles coated by PEG (BN-PEG) with smaller size (similar to 10 nm), then studied their biodistribution in vivo through radioisotope ((TcO4-)-O-99m) labeling, and the results showed that BN-PEG nanoparticles mainly accumulated in the liver, lung, and spleen with the less uptake by the brain. Moreover, the pathological changes induced by BN-PEG could be significantly observed in the sections of the liver, lung, spleen, and heart, which can be also supported by the test of biochemical indexes in serum. More importantly, we first observed the biodistribution of BN-PEG in the heart tissues with high toxicity, which would give a warning about the cardiovascular disease, and provide some opportunities for the drug delivery and treatment.
WOS关键词	GRAPHENE OXIDE ; DRUG-DELIVERY ; NANOTUBES ; FILMS
WOS研究方向	Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000366347600002
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/171524]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Qi, Wei
作者单位	1.Huazhong Univ Sci & Technol, Wuhan 430074, Peoples R China 2.Lanzhou Univ, Radiochem Lab, Lanzhou 730000, Gansu, Peoples R China 3.Chinese Acad Sci, Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Gansu, Peoples R China 4.Gansu Prov Hosp, Dept Radiotherapy, Lanzhou 730000, Gansu, Peoples R China 5.Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Gansu, Peoples R China 6.Nanchang Univ, Dept Chem, Nanchang 330031, Peoples R China
推荐引用方式 GB/T 7714	Liu, Bo,Qi, Wei,Tian, Longlong,et al. In Vivo Biodistribution and Toxicity of Highly Soluble PEG-Coated Boron Nitride in Mice[J]. NANOSCALE RESEARCH LETTERS,2015,10.
APA	Liu, Bo.,Qi, Wei.,Tian, Longlong.,Li, Zhan.,Miao, Guoying.,...&Wu, Wangsuo.(2015).In Vivo Biodistribution and Toxicity of Highly Soluble PEG-Coated Boron Nitride in Mice.NANOSCALE RESEARCH LETTERS,10.
MLA	Liu, Bo,et al."In Vivo Biodistribution and Toxicity of Highly Soluble PEG-Coated Boron Nitride in Mice".NANOSCALE RESEARCH LETTERS 10(2015).