Rh(III)-Catalyzed Synthesis of N-Unprotected Indoles from Imidamides and Diazo Ketoesters via C-H Activation and C-C/C-N Bond Cleavage

doi:10.1021/acs.orglett.5b03669

	Rh(III)-Catalyzed Synthesis of N-Unprotected Indoles from Imidamides and Diazo Ketoesters via C-H Activation and C-C/C-N Bond Cleavage
	Li, Xingwei; Qi, Zisong; Yu, Songjie
刊名	ORGANIC LETTERS
	2016-02-19
卷号	18 期号:4 页码:700-703
ISSN号	1523-7060
DOI	10.1021/acs.orglett.5b03669
文献子类	Article
英文摘要	The synthesis of N-unprotected indoles has been realized via Rh(III)-catalyzed C-H activation/annulation of imidamides with alpha-diazo beta-ketoesters. The reaction occurs with the release of an amide coproduct, which originates from both the imidamide and the diazo as a result of C=N cleavage of the imidamide and C-C(acyl) cleavage of the diazo. A rhodacyclic intermediate has been isolated and a plausible mechanism has been proposed.
WOS关键词	NONREARRANGED MONOTERPENOID UNIT ; PALLADIUM-CATALYZED REACTIONS ; 2,3-DISUBSTITUTED INDOLES ; ONE-POT ; REGIOSPECIFIC SYNTHESIS ; C(SP(3))-H ACTIVATION ; SUBSTITUTED INDOLES ; INTERNAL ALKYNES ; COMPOUNDS ACCESS ; DIRECTING GROUP
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000370768200019
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/171300]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Li, Xingwei
作者单位	Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Li, Xingwei,Qi, Zisong,Yu, Songjie. Rh(III)-Catalyzed Synthesis of N-Unprotected Indoles from Imidamides and Diazo Ketoesters via C-H Activation and C-C/C-N Bond Cleavage[J]. ORGANIC LETTERS,2016,18(4):700-703.
APA	Li, Xingwei,Qi, Zisong,&Yu, Songjie.(2016).Rh(III)-Catalyzed Synthesis of N-Unprotected Indoles from Imidamides and Diazo Ketoesters via C-H Activation and C-C/C-N Bond Cleavage.ORGANIC LETTERS,18(4),700-703.
MLA	Li, Xingwei,et al."Rh(III)-Catalyzed Synthesis of N-Unprotected Indoles from Imidamides and Diazo Ketoesters via C-H Activation and C-C/C-N Bond Cleavage".ORGANIC LETTERS 18.4(2016):700-703.