Small-Protein-Stabilized Semiconductor Nanoprobe for Targeted Imaging of Cancer Cells

doi:10.1002/cbic.201600219

	Small-Protein-Stabilized Semiconductor Nanoprobe for Targeted Imaging of Cancer Cells
	Jiang, Qike 3; Lan, Tian 1; Cheng, Zhen 2; Zhao, Ning 1; Liu, Hongguang 1; Liu, Siyu 1
刊名	CHEMBIOCHEM
	2016-07-01
卷号	17 期号:13 页码:1202-1206
关键词	Affibody Her2 Fluorescent Imaging One-pot Synthesis Quantum Dots
ISSN号	1439-4227
DOI	10.1002/cbic.201600219
文献子类	Article
英文摘要	Recently, semiconductor nanoparticles such as quantum dots (QDs) have attracted significant attention for bioimaging. Complex chemical functionalization, surface modification, and bioconjugation chemistry are generally required to tag biomolecules to QDs for imaging of different biomarkers. In this study, we report a simple method for production of QDs stabilized by the small protein, Affibody (AF-QDs) for fluorescent imaging of the human epidermal growth factor receptor type2 (HER2) in human A549 lung cancer cells. This one-pot synthesis of AF-QDs avoids complex chemical conjugation procedures and demonstrates a promising approach for the preparation of fluorescent nanoprobes for imaging of cancer targets.
WOS关键词	QUANTUM DOTS ; BREAST-CANCER ; ANTI-HER2 ANTIBODY ; IN-VIVO ; NANOPARTICLES ; TUMORS ; HER2 ; LUNG ; PET
WOS研究方向	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000379826400003
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/170366]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Cheng, Zhen; Liu, Hongguang
作者单位	1.Northeastern Univ, Inst Mol Med, Coll Life & Hlth Sci, 195 Chuangxin Rd, Shenyang 110000, Japan 2.Stanford Univ, Dept Radiol, Mol Imaging Program Stanford, 1201 Welch Rd, Stanford, CA 94040 USA 3.Chinese Acad Sci, Dalian Inst Chem Phys, 457 Zhongshan Rd, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Jiang, Qike,Lan, Tian,Cheng, Zhen,et al. Small-Protein-Stabilized Semiconductor Nanoprobe for Targeted Imaging of Cancer Cells[J]. CHEMBIOCHEM,2016,17(13):1202-1206.
APA	Jiang, Qike,Lan, Tian,Cheng, Zhen,Zhao, Ning,Liu, Hongguang,&Liu, Siyu.(2016).Small-Protein-Stabilized Semiconductor Nanoprobe for Targeted Imaging of Cancer Cells.CHEMBIOCHEM,17(13),1202-1206.
MLA	Jiang, Qike,et al."Small-Protein-Stabilized Semiconductor Nanoprobe for Targeted Imaging of Cancer Cells".CHEMBIOCHEM 17.13(2016):1202-1206.