Three Novel Alkaloids from Portulaca oleracea L. and Their Antiinflammatory Effects

doi:10.1021/acs.jafc.6b02673

	Three Novel Alkaloids from Portulaca oleracea L. and Their Antiinflammatory Effects
	Ying, Zhe-Ming 2; Li, Cui-Yu 1; Meng, Yi-Han 1; Xu, Nan 1; Hao, Dong 1; Gao, Ming-Zhe 3; Zhang, Wen-Jie 1; Xu, Liang 1; Gao, Yu-Cong 1; Ying, Xi-Xiang 1
刊名	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
	2016-07-27
卷号	64 期号:29 页码:5837-5844
关键词	PortuL.ca OL.racea L. Alkaloids Anti-inflammatory Effects
ISSN号	0021-8561
DOI	10.1021/acs.jafc.6b02673
文献子类	Article
英文摘要	Three novel carbon skeleton alkaloids, named oleracimine (1), oleracimine A (2), and oleracone A (3), with one novel azulene carbon skeleton compound, oleracone B (4), and one known compound, beta-carboline (5), were first isolated from Portulaca oleracea L. The structures were determined using spectroscopic methods, including one- and two-dimensional nuclear magnetic resonance and high-resolution electrospray ionization time-of-flight mass spectrometry techniques. In addition, oleracimine (1) was used to investigate the anti-inflammatory effects on lipopolysaccharide-stimulated macrophages. The results of enzyme-linked immunosorbent assay, western blot, and real-time polymerase chain reaction showed that oleracimine (1) remarkably inhibited nitric oxide production and could dose-dependently decrease the secretions of interleukin 6, tumor necrosis factor a, nitric oxide, and prostaglandin E-2 in cell culture supernatants as well as the mRNA of cyclooxygenase-2 and inducible nitric oxide synthase.
WOS关键词	NITRIC-OXIDE ; AQUEOUS EXTRACT ; TNF-ALPHA ; IN-VIVO ; INFLAMMATION ; EXPRESSION ; RESPONSES ; STRESS ; PROSTAGLANDINS ; SUPPRESSION
WOS研究方向	Agriculture ; Chemistry ; Food Science & Technology
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000380735200007
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/170014]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Ying, Xi-Xiang
作者单位	1.Liaoning Univ Tradit Chinese Med, Sch Pharm, Dalian 116600, Liaoning, Peoples R China 2.Liaoning Univ Tradit Chinese Med, Sch Clin 1, Shenyang 110032, Liaoning, Peoples R China 3.Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Ying, Zhe-Ming,Li, Cui-Yu,Meng, Yi-Han,et al. Three Novel Alkaloids from Portulaca oleracea L. and Their Antiinflammatory Effects[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2016,64(29):5837-5844.
APA	Ying, Zhe-Ming.,Li, Cui-Yu.,Meng, Yi-Han.,Xu, Nan.,Hao, Dong.,...&Ying, Xi-Xiang.(2016).Three Novel Alkaloids from Portulaca oleracea L. and Their Antiinflammatory Effects.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,64(29),5837-5844.
MLA	Ying, Zhe-Ming,et al."Three Novel Alkaloids from Portulaca oleracea L. and Their Antiinflammatory Effects".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 64.29(2016):5837-5844.