Reversibly monitoring oxidation and reduction events in living biological systems: Recent development of redox-responsive reversible NIR biosensors and their applications in in vitro/in vivo fluorescence imaging

doi:10.1016/j.bios.2016.07.039

	Reversibly monitoring oxidation and reduction events in living biological systems: Recent development of redox-responsive reversible NIR biosensors and their applications in in vitro/in vivo fluorescence imaging
	Chu, Tian-shu 1,2,3; Lu, Rui 4; Liu, Bai-tong 1,5
刊名	BIOSENSORS & BIOELECTRONICS
	2016-12-15
卷号	86 页码:643-655
关键词	Redox-responsive Reversible Nir Biosensor Reactive Oxygen Species Redox Changes In vitro/In Vivo Fluorescence imagIng Living Cells And Small Animals
ISSN号	0956-5663
DOI	10.1016/j.bios.2016.07.039
文献子类	Review
英文摘要	Reactive oxygen species (ROS) and changes in their redox cycles have great therapeutic potential for treating serious redox-related human diseases such as acute and chronic inflammation, diabetes, cancer and neurodegenerative disorders. This article presents a survey of the recently (2011-2016) developed NIR small-molecule biosensors for reversibly monitoring oxidation and reduction events in living cells and small animals through in vitro/in vivo fluorescence imaging. Emission and absorption profile, design strategy and fluorescence sensing mechanism, ROS selectivity and sensitivity, reversibility, ability of subcellular location and cytotoxicity are discussed for the NIR small-molecule biosensors capable of quantitatively, continuously and reversibly detecting transient ROS burst and redox changes at cellular level. (C) 2016 Elsevier B.V. All rights reserved.
WOS关键词	PHOTOINDUCED ELECTRON-TRANSFER ; THIOLS REDUCING REPAIR ; STATE PROTON-TRANSFER ; SENSING MECHANISM ; PHOTOPHYSICAL PROPERTIES ; HYDROGEN-SULFIDE ; HYPOBROMOUS ACID ; HYPOCHLORIC ACID ; LIVE CELLS ; SE-BODIPY
WOS研究方向	Biophysics ; Biotechnology & Applied Microbiology ; Chemistry ; Electrochemistry ; Science & Technology - Other Topics
语种	英语
出版者	ELSEVIER ADVANCED TECHNOLOGY
WOS记录号	WOS:000384853300089
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/169844]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Chu, Tian-shu
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Mol React Dynam, Dalian 116023, Peoples R China 2.Qingdao Univ, Inst Computat Sci & Engn, Lab New Fiber Mat & Modern Text, Growing Base State Key Lab, Qingdao 266071, Peoples R China 3.Qingdao Univ, Coll Phys, Qingdao 266071, Peoples R China 4.Qingdao Univ, Coll Med, Lab Pathogen Biol, Qingdao 266071, Peoples R China 5.Qingdao Univ, Coll Chem Sci & Engn, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Chu, Tian-shu,Lu, Rui,Liu, Bai-tong. Reversibly monitoring oxidation and reduction events in living biological systems: Recent development of redox-responsive reversible NIR biosensors and their applications in in vitro/in vivo fluorescence imaging[J]. BIOSENSORS & BIOELECTRONICS,2016,86:643-655.
APA	Chu, Tian-shu,Lu, Rui,&Liu, Bai-tong.(2016).Reversibly monitoring oxidation and reduction events in living biological systems: Recent development of redox-responsive reversible NIR biosensors and their applications in in vitro/in vivo fluorescence imaging.BIOSENSORS & BIOELECTRONICS,86,643-655.
MLA	Chu, Tian-shu,et al."Reversibly monitoring oxidation and reduction events in living biological systems: Recent development of redox-responsive reversible NIR biosensors and their applications in in vitro/in vivo fluorescence imaging".BIOSENSORS & BIOELECTRONICS 86(2016):643-655.