Radical-Mediated 1,2-Formyl/Carbonyl Functionalization of Alkenes and Application to the Construction of Medium-Sized Rings

doi:10.1002/anie.201608198

	Radical-Mediated 1,2-Formyl/Carbonyl Functionalization of Alkenes and Application to the Construction of Medium-Sized Rings
	Li, Xiao-Hua 1; Wang, Na 1; Yang, Ning-Yuan 1; Liu, Xin-Yuan 1; Li, Zhong-Liang 1,2
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2016-11-21
卷号	55 期号:48 页码:15100-15104
关键词	Alkenes Heterocycles Medium-ring Systems Radicals Synthetic Methods
ISSN号	1433-7851
DOI	10.1002/anie.201608198
文献子类	Article
英文摘要	A novel radical 1,2-formylfunctionalization of alkenes involving 1,2(4,5)-formyl migration triggered by addition of various carbon- and heteroatom-centered radicals to alkenes has been developed for the first time, thus providing straightforward access to diverse beta-functionalized aldehydes with good efficiency, remarkable selectivity, and excellent functional group tolerance. Analogous transformations mediated by a keto-carbonyl migration have also been effected under similar conditions. This method was used to access ring systems including various benzannulated nine-, ten-, and eleven-membered rings, complex 6-5(6,7)-6(5) fused rings, and bridged rings with diverse functionalities.
WOS关键词	LIGHT PHOTOREDOX CATALYSIS ; HYDROGEN-ATOM TRANSFER ; C-H FUNCTIONALIZATION ; ORGANIC-SYNTHESIS ; CARBON RADICALS ; TRIFLUOROMETHYLTHIOLATION REACTIONS ; OXIDATIVE TRIFLUOROMETHYLATION ; FRAGMENTATION REACTIONS ; BETA-FRAGMENTATION ; CYCLIZATION
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000388258000038
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/169762]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Liu, Xin-Yuan
作者单位	1.South Univ Sci & Technol China, Dept Chem, Shenzhen 518055, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Li, Xiao-Hua,Wang, Na,Yang, Ning-Yuan,et al. Radical-Mediated 1,2-Formyl/Carbonyl Functionalization of Alkenes and Application to the Construction of Medium-Sized Rings[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2016,55(48):15100-15104.
APA	Li, Xiao-Hua,Wang, Na,Yang, Ning-Yuan,Liu, Xin-Yuan,&Li, Zhong-Liang.(2016).Radical-Mediated 1,2-Formyl/Carbonyl Functionalization of Alkenes and Application to the Construction of Medium-Sized Rings.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,55(48),15100-15104.
MLA	Li, Xiao-Hua,et al."Radical-Mediated 1,2-Formyl/Carbonyl Functionalization of Alkenes and Application to the Construction of Medium-Sized Rings".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 55.48(2016):15100-15104.