A Hydrogenation/Oxidative Fragmentation Cascade for Synthesis of Chiral 4,5-Dihydro-1H-benzo[d]azepin-1-ones

doi:10.1021/acs.orglett.6b03027

	A Hydrogenation/Oxidative Fragmentation Cascade for Synthesis of Chiral 4,5-Dihydro-1H-benzo[d]azepin-1-ones
	Liu, Cong 3; Zhou, Yong-Gui 2,3; Shen, Hong-Qiang 1,3; Gao, Xiang 3; Hu, Shu-Bo 3
刊名	ORGANIC LETTERS
	2016-11-18
卷号	18 期号:22 页码:5920-5923
ISSN号	1523-7060
DOI	10.1021/acs.orglett.6b03027
文献子类	Article
英文摘要	An iridium-catalyzed asymmetric hydrogenation/oxidative fragmentation of 6 -substituted 5H-benzo [d] benzofuro[3,2-b]azepines has been developed, providing an efficient access to optically active 4-substituted 4,5-dihydro-1H-benzo[d]azepin-l-ones with up to 91% ee. A possible reaction pathway includes the asymmetric hydrogenation to furnish chiral cyclic amines and oxidative fragmentation under an air atmosphere..
WOS关键词	CATALYZED ASYMMETRIC HYDROGENATION ; MOLECULAR-OXYGEN ; RECEPTOR AGONISTS ; CYCLIC IMINES ; OXIDATION ; DERIVATIVES ; DISCOVERY ; 3-BENZAZEPINES ; ISOQUINOLINES ; HYDROXYLATION
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000388428600038
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/169752]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Zhou, Yong-Gui
作者单位	1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300071, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Liu, Cong,Zhou, Yong-Gui,Shen, Hong-Qiang,et al. A Hydrogenation/Oxidative Fragmentation Cascade for Synthesis of Chiral 4,5-Dihydro-1H-benzo[d]azepin-1-ones[J]. ORGANIC LETTERS,2016,18(22):5920-5923.
APA	Liu, Cong,Zhou, Yong-Gui,Shen, Hong-Qiang,Gao, Xiang,&Hu, Shu-Bo.(2016).A Hydrogenation/Oxidative Fragmentation Cascade for Synthesis of Chiral 4,5-Dihydro-1H-benzo[d]azepin-1-ones.ORGANIC LETTERS,18(22),5920-5923.
MLA	Liu, Cong,et al."A Hydrogenation/Oxidative Fragmentation Cascade for Synthesis of Chiral 4,5-Dihydro-1H-benzo[d]azepin-1-ones".ORGANIC LETTERS 18.22(2016):5920-5923.