Two-dimensional solid-phase extraction strategy for the selective enrichment of aminoglycosides in milk

doi:10.1002/jssc.201601086

	Two-dimensional solid-phase extraction strategy for the selective enrichment of aminoglycosides in milk
	Ding, Junjie 2; Shen, Aijin 2; Wei, Jie 1; Yan, Jingyu 2; Jin, Gaowa 2; Yang, Bingcheng 1; Guo, Zhimou 2; Zhang, Feifang 1,2; Liang, Xinmiao 1,2
刊名	JOURNAL OF SEPARATION SCIENCE
	2017-03-01
卷号	40 期号:5 页码:1099-1106
关键词	Aminoglycosides Reversed-phase Liquid Chromatography Solid-phase Extraction Tandem Mass Spectrometry Weak Cation-exchange Chromatography
ISSN号	1615-9306
DOI	10.1002/jssc.201601086
文献子类	Article
英文摘要	An orthogonal two-dimensional solid-phase extraction strategy was established for the selective enrichment of three aminoglycosides including spectinomycin, streptomycin, and dihydrostreptomycin in milk. A reversed-phase liquid chromatography material (C-18) and a weak cation-exchange material (TGA) were integrated in a single solid-phase extraction cartridge. The feasibility of two-dimensional clean-up procedure that experienced two-step adsorption, two-step rinsing, and two-step elution was systematically investigated. Based on the orthogonality of reversed-phase and weak cation-exchange procedures, the twodimensional solid-phase extraction strategy could minimize the interference from the hydrophobic matrix existing in traditional reversed-phase solid-phase extraction. In addition, high ionic strength in the extracts could be effectively removed before the second dimension of weak cation-exchange solid-phase extraction. Combined with liquid chromatography and tandem mass spectrometry, the optimized procedure was validated according to the European Union Commission directive 2002/657/EC. A good performance was achieved in terms of linearity, recovery, precision, decision limit, and detection capability in milk. Finally, the optimized two-dimensional clean-up procedure incorporated with liquid chromatography and tandem mass spectrometry was successfully applied to the rapid monitoring of aminoglycoside residues in milk.
WOS关键词	TANDEM MASS-SPECTROMETRY ; LIQUID-CHROMATOGRAPHY ; HYDROPHILIC INTERACTION ; ANIMAL ORIGIN ; RESIDUES ; DIHYDROSTREPTOMYCIN ; STREPTOMYCIN ; ANTIBIOTICS ; KIDNEY ; BOVINE
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000397829700010
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/169438]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Guo, Zhimou; Zhang, Feifang; Liang, Xinmiao
作者单位	1.East China Univ Sci & Technol, Sch Pharm, Shanghai, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
推荐引用方式 GB/T 7714	Ding, Junjie,Shen, Aijin,Wei, Jie,et al. Two-dimensional solid-phase extraction strategy for the selective enrichment of aminoglycosides in milk[J]. JOURNAL OF SEPARATION SCIENCE,2017,40(5):1099-1106.
APA	Ding, Junjie.,Shen, Aijin.,Wei, Jie.,Yan, Jingyu.,Jin, Gaowa.,...&Liang, Xinmiao.(2017).Two-dimensional solid-phase extraction strategy for the selective enrichment of aminoglycosides in milk.JOURNAL OF SEPARATION SCIENCE,40(5),1099-1106.
MLA	Ding, Junjie,et al."Two-dimensional solid-phase extraction strategy for the selective enrichment of aminoglycosides in milk".JOURNAL OF SEPARATION SCIENCE 40.5(2017):1099-1106.