Combining cooperativity with sequestration: a novel strategy for discrimination of single nucleotide variants

doi:10.1039/c8cc00838h

	Combining cooperativity with sequestration: a novel strategy for discrimination of single nucleotide variants
	Hu, Shichao; Liu, Feng; Li, Na
刊名	CHEMICAL COMMUNICATIONS
	2018-04-04
卷号	54 期号:26 页码:3223-3226
ISSN号	1359-7345
DOI	10.1039/c8cc00838h
文献子类	Article
英文摘要	We present a novel strategy for the discrimination of single nucleotide variants (SNVs) by combining cooperativity with sequestration, which displays remarkably high specificity (discrimination factors ranging from 67 to 618 with a median of 194) against 12 model SNVs and can be easily integrated with PCR amplification to detect KRAS G12Dmutation.
WOS关键词	NUCLEIC-ACIDS ; FLUORESCENCE DETECTION ; MOLECULAR BEACONS ; RATIONAL DESIGN ; DNA-PROBE ; HYBRIDIZATION ; AMPLIFICATION ; POPULATION ; ASSAY ; POLYMORPHISMS
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000428553500006
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/169146]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Liu, Feng
作者单位	Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Coll Chem & Mol Engn, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Hu, Shichao,Liu, Feng,Li, Na. Combining cooperativity with sequestration: a novel strategy for discrimination of single nucleotide variants[J]. CHEMICAL COMMUNICATIONS,2018,54(26):3223-3226.
APA	Hu, Shichao,Liu, Feng,&Li, Na.(2018).Combining cooperativity with sequestration: a novel strategy for discrimination of single nucleotide variants.CHEMICAL COMMUNICATIONS,54(26),3223-3226.
MLA	Hu, Shichao,et al."Combining cooperativity with sequestration: a novel strategy for discrimination of single nucleotide variants".CHEMICAL COMMUNICATIONS 54.26(2018):3223-3226.