Synthesis and chromatographic evaluation of phenyl/tetrazole bonded stationary phase based on thiol-epoxy ring opening reaction

doi:10.1002/jssc.201701125

	Synthesis and chromatographic evaluation of phenyl/tetrazole bonded stationary phase based on thiol-epoxy ring opening reaction
	Jin, Gaowa 2; Liu, Yanming 1; Yang, Fan 2; Yu, Dongping 2; Yan, Jingyu 2; Zhou, Weijia 2; Guo, Zhimou 2,3; Zhu, Jianhua 1; Liang, Xinmiao 2,3
刊名	JOURNAL OF SEPARATION SCIENCE
	2018-02-01
卷号	41 期号:4 页码:856-867
关键词	Reversed-phase Liquid Chromatography Stationary Phases Thiol-epoxy Ring Opening Reaction Traditional Chinese Medicine Two-dimensional Liquid Chromatography
ISSN号	1615-9306
DOI	10.1002/jssc.201701125
文献子类	Article
英文摘要	A silica-based reversed-phase stationary phase bonding with phenyl and tetrazole groups was synthesized by thiol-epoxy ring opening reaction. The bonded groups could not only provide hydrophobic interaction, but also -, hydrogen bonding, electrostatic interactions, and so on. The results of characterization with elemental analysis and solid-state C-13 cross-polarization magic-angle-spinning NMR spectroscopy indicated the successful preparation of phenyl/tetrazole sulfoether bonded stationary phase. Chromatographic evaluation revealed that phenyl/tetrazole sulfoether bonded stationary phase behaved well under the reversed-phase mode. The column parameters (H, S*, A, B, and C) showed different selectivity compared with some typical commercial columns, and it was validated by the separation of estrogen, ginsenoside, alkaloid samples. Based on the different selectivity between phenyl/tetrazole sulfoether bonded stationary phase and C18 columns, phenyl/tetrazole sulfoether bonded stationary phase also showed potential to construct a 2D reversed-phase liquid chromatography system with C18. And it was verified by the separation of corydalis tuber and curcuma zedoary extracts.
WOS关键词	PERFORMANCE LIQUID-CHROMATOGRAPHY ; ANION-EXCHANGE CHROMATOGRAPHY ; ALKYL-SILICA COLUMNS ; REVERSED-PHASE ; RP-HPLC ; RETENTION MECHANISM ; SELECTIVITY ; SEPARATION ; PEPTIDE ; PROTEINS
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000425741100006
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/168810]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Guo, Zhimou
作者单位	1.Shandong Inst Food & Drug Control, Jinan, Shandong, Peoples R China 2.Chinese Acad Sci, CAS Key Lab Separat Sci Analyt Chem, Dalian Inst Chem Phys, Dalian, Peoples R China 3.Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong, Peoples R China
推荐引用方式 GB/T 7714	Jin, Gaowa,Liu, Yanming,Yang, Fan,et al. Synthesis and chromatographic evaluation of phenyl/tetrazole bonded stationary phase based on thiol-epoxy ring opening reaction[J]. JOURNAL OF SEPARATION SCIENCE,2018,41(4):856-867.
APA	Jin, Gaowa.,Liu, Yanming.,Yang, Fan.,Yu, Dongping.,Yan, Jingyu.,...&Liang, Xinmiao.(2018).Synthesis and chromatographic evaluation of phenyl/tetrazole bonded stationary phase based on thiol-epoxy ring opening reaction.JOURNAL OF SEPARATION SCIENCE,41(4),856-867.
MLA	Jin, Gaowa,et al."Synthesis and chromatographic evaluation of phenyl/tetrazole bonded stationary phase based on thiol-epoxy ring opening reaction".JOURNAL OF SEPARATION SCIENCE 41.4(2018):856-867.