Pharmacokinetics and metabolism of olerciamide A from Portulaca oleracea L. in rats by UHPLC-UV and UHPLC-ESI-Q-TOF/MS

doi:10.1002/bmc.4061

	Pharmacokinetics and metabolism of olerciamide A from Portulaca oleracea L. in rats by UHPLC-UV and UHPLC-ESI-Q-TOF/MS
	Ying, Zheming 2; Li, Cuiyu 3; Gao, Mingzhe 1; Ying, Xixiang 3; Yang, Guanlin 2
刊名	BIOMEDICAL CHROMATOGRAPHY
	2018-02-01
卷号	32 期号:2
关键词	Metabolism Olerciamide a Pharmacokinetics Portulaca Oleracea l Ultra-high Performance Liquid Chromatography Ultra-high Performance Liquid Chromatography Electrospray Quadrupole-time Of Flight Mass Spectrometry
ISSN号	0269-3879
DOI	10.1002/bmc.4061
文献子类	Article
英文摘要	The aim of this study was to elucidate the pharmacokinetics of olerciamide A in rats after oral and intravenous administration of Portulaca oleracea L. extract by a simple and rapid ultra high-performance liquid chromatography method with bergapten as internal standard. The pharmacokinetic results indicated that olerciamide A was rapidly distributed with a time to peak concentration of 30min after oral administration and presented a low oral absolute bioavailability of 4.57%. The metabolism of olerciamide A in rats was also investigated using ultra-high-performance liquid chromatography electrospray coupled with quadrupole-time of flight mass spectrometry to elucidate the reason for the low absolute bioavailability of olerciamide A and seven metabolites of oleraciamide A were found in rat plasma and urine.
WOS关键词	FLIGHT MASS-SPECTROMETRY ; ALKALOIDS ; IDENTIFICATION ; TIME ; ACID
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	WILEY
WOS记录号	WOS:000423404000024
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/168644]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Ying, Xixiang; Yang, Guanlin
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Liaoning, Peoples R China 2.Liaoning Univ Tradit Chinese Med, Sch Clin 1, Shenyang 110032, Liaoning, Peoples R China 3.Liaoning Univ Tradit Chinese Med, Sch Pharm, Dalian 116600, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Ying, Zheming,Li, Cuiyu,Gao, Mingzhe,et al. Pharmacokinetics and metabolism of olerciamide A from Portulaca oleracea L. in rats by UHPLC-UV and UHPLC-ESI-Q-TOF/MS[J]. BIOMEDICAL CHROMATOGRAPHY,2018,32(2).
APA	Ying, Zheming,Li, Cuiyu,Gao, Mingzhe,Ying, Xixiang,&Yang, Guanlin.(2018).Pharmacokinetics and metabolism of olerciamide A from Portulaca oleracea L. in rats by UHPLC-UV and UHPLC-ESI-Q-TOF/MS.BIOMEDICAL CHROMATOGRAPHY,32(2).
MLA	Ying, Zheming,et al."Pharmacokinetics and metabolism of olerciamide A from Portulaca oleracea L. in rats by UHPLC-UV and UHPLC-ESI-Q-TOF/MS".BIOMEDICAL CHROMATOGRAPHY 32.2(2018).