A ratiometric time-gated luminescence probe for hydrogen sulfide based on copper(II)-coupled lanthanide complexes

doi:10.1016/j.aca.2018.10.048

	A ratiometric time-gated luminescence probe for hydrogen sulfide based on copper(II)-coupled lanthanide complexes
	Song, Bo 1; Yuan, Jingli 1; Ma, Hua 1; Shi, Yuanyuan 2; Tang, Zhixin 1
刊名	ANALYTICA CHIMICA ACTA
	2019-02-21
卷号	1049 页码:152-160
关键词	Lanthanide complex Time-gated luminescence Hydrogen sulfide Ratiometric luminescence probe Bioimaging
ISSN号	0003-2670
DOI	10.1016/j.aca.2018.10.048
通讯作者	Song, Bo(bo.song@dlut.edu.cn) ; Yuan, Jingli(jlyuan@dlut.edu.cn)
英文摘要	Time-gated luminescence (TGL) bioassay technique using luminescent lanthanide complexes as probes has exhibited excellent practicability in detection of various analytes in autofluorescence-rich biosamples. Herein, a novel copper(II)-coupled lanthanide complex-based luminescence probe has been developed for the ratiometric TGL detection of hydrogen sulfide (H2S) in vitro and in vivo. The probe is constructed based on a dual-functional ligand that was synthesized by conjugating di(2-picolyl)amine with terpyridine polyacid (DATP) using the "click chemistry" method. The as-prepared ligand can coordinate to Eu3+ and Tb3+ ions with its terpyridine polyacid moiety to display long-lived emissions of Eu3+ and Tb3+ ions, while the further coordination of its di(2-picolyl)amino moiety to Cu2+ induces to the luminescence quenching of the Eu3+ complexes, which allows the probe consisting of the heterometallic Cu2+-DATP-Eu3+/Tb3+ complexes to be constructed. After the probe was reacted with H2S to lead to the release of Cu2+ from the complexes, the emission of Eu3+ at 610 nm was remarkably enhanced, while that of Tb3+ at 540 nm was changed slightly. This luminescence response feature allowed the probe to be conveniently applied for the ratiometric TGL determination of H2S with I-610/I-540 as the signal. The applicability of the probe for quantitative detection of H2S in human sera as well as for imaging of H2S in living cells and zebrafish were evaluated. All of the results proved the potential of the probe for in vitro and in vivo applications. (C) 2018 Elsevier B.V. All rights reserved.
资助项目	National Natural Science Foundation of China[21477011] ; National Natural Science Foundation of China[21775015] ; National Natural Science Foundation of China[21475016]
WOS关键词	FLUORESCENT-PROBE ; CELLS ; SULFUR ; ROLES ; ASSAY ; H2S
WOS研究方向	Chemistry
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000454789100017
资助机构	National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/166340]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Song, Bo; Yuan, Jingli
作者单位	1.Dalian Univ Technol, Sch Chem, State Key Lab Fine Chem, Dalian 116024, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Gold Catalysis Res Ctr, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Song, Bo,Yuan, Jingli,Ma, Hua,et al. A ratiometric time-gated luminescence probe for hydrogen sulfide based on copper(II)-coupled lanthanide complexes[J]. ANALYTICA CHIMICA ACTA,2019,1049:152-160.
APA	Song, Bo,Yuan, Jingli,Ma, Hua,Shi, Yuanyuan,&Tang, Zhixin.(2019).A ratiometric time-gated luminescence probe for hydrogen sulfide based on copper(II)-coupled lanthanide complexes.ANALYTICA CHIMICA ACTA,1049,152-160.
MLA	Song, Bo,et al."A ratiometric time-gated luminescence probe for hydrogen sulfide based on copper(II)-coupled lanthanide complexes".ANALYTICA CHIMICA ACTA 1049(2019):152-160.