One-step fabrication of cinchona-based hybrid monolithic chiral stationary phases via photo-initiated thiol-ene polymerization for cLC enantioseparation

doi:10.1016/j.talanta.2019.02.046

	One-step fabrication of cinchona-based hybrid monolithic chiral stationary phases via photo-initiated thiol-ene polymerization for cLC enantioseparation
	Ye, Mingliang 1; Ma, Shujuan 1,2; Wang, Yan 1,2; Zhang, Haiyang 1,2; Li, Ya 1,2; Ou, Junjie 1; Wei, Yinmao 2
刊名	TALANTA
	2019-06-01
卷号	198 页码:432-439
关键词	Chiral stationary phase Hybrid monolith Thiol-ene click reaction Capillary liquid chromatography Polyhedral oligomeric silsesquioxanes
ISSN号	0039-9140
DOI	10.1016/j.talanta.2019.02.046
通讯作者	Ou, Junjie(junjieou@dicp.ac.cn) ; Wei, Yinmao(ymwei@nwu.edu.cn)
英文摘要	Although various click polymerization reactions (thiol-ene, thiol-yne, thiol-Michael, thiol-epoxy and amine epoxy) have been utilized to prepare either hybrid or organic monolithic columns with homogeneous network structures, there were few reports on fabrication of monolithic CSPs via click polymerization. Herein, a fast and robust approach was explored to fabricate cinchona-based monolithic hybrid CSPs via photo-initiated thiol-ene polymerization within 10 min in one step. A self-synthesized octakis(3-mercaptopropyl) octasilsesquioxane (POSS-SH) was polymerized with phenylisocyanate cinchonidine (PCD) and (+)-N,N'-diallyl-L-tartardiamide (DATDA) or 1,2,4-trivinylcyclohexane (TVCH). The resulting two kinds of as-synthesized monolithic CSPs, poly (POSS-co-DATDA-co-PCD) and poly(POSS-co-TVCH-co-PCD), were evaluated for cLC enantioseparation of acidic racemates. It was found that they exhibited different enantioseparation ability due to using different multivinyl crosslinkers. The influence of ACN content in mobile phase on the enantioseparation of acidic racemates was investigated. The separation mechanism was also discussed on the basis of a comparison of enantioseparation on two kinds of hybrid monolithic CSPs.
资助项目	China State Key Basic Research Program Grant[2016YFA0501402] ; National Science Fund for Distinguished Young Scholars[21525524] ; National Natural Science Foundation of China[21575141] ; CAS-Weigao Research & Development Program[[2017]-009]
WOS关键词	RING-OPENING POLYMERIZATION ; LIQUID-CHROMATOGRAPHY ; CLICK POLYMERIZATION ; CAPILLARY COLUMNS ; ACRYLATE POLYMERIZATION ; RADICAL POLYMERIZATION ; CROSS-LINKER ; AMINO-ACIDS ; PERFORMANCE ; SEPARATION
WOS研究方向	Chemistry
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000462803400057
资助机构	China State Key Basic Research Program Grant ; China State Key Basic Research Program Grant ; National Science Fund for Distinguished Young Scholars ; National Science Fund for Distinguished Young Scholars ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; CAS-Weigao Research & Development Program ; CAS-Weigao Research & Development Program ; China State Key Basic Research Program Grant ; China State Key Basic Research Program Grant ; National Science Fund for Distinguished Young Scholars ; National Science Fund for Distinguished Young Scholars ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; CAS-Weigao Research & Development Program ; CAS-Weigao Research & Development Program ; China State Key Basic Research Program Grant ; China State Key Basic Research Program Grant ; National Science Fund for Distinguished Young Scholars ; National Science Fund for Distinguished Young Scholars ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; CAS-Weigao Research & Development Program ; CAS-Weigao Research & Development Program ; China State Key Basic Research Program Grant ; China State Key Basic Research Program Grant ; National Science Fund for Distinguished Young Scholars ; National Science Fund for Distinguished Young Scholars ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; CAS-Weigao Research & Development Program ; CAS-Weigao Research & Development Program
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/165566]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Ou, Junjie; Wei, Yinmao
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Northwest Univ, Coll Chem & Mat Sci, Minist Educ, Key Lab Synthet & Nat Funct Mol Chem, Xian 710069, Shaanxi, Peoples R China
推荐引用方式 GB/T 7714	Ye, Mingliang,Ma, Shujuan,Wang, Yan,et al. One-step fabrication of cinchona-based hybrid monolithic chiral stationary phases via photo-initiated thiol-ene polymerization for cLC enantioseparation[J]. TALANTA,2019,198:432-439.
APA	Ye, Mingliang.,Ma, Shujuan.,Wang, Yan.,Zhang, Haiyang.,Li, Ya.,...&Wei, Yinmao.(2019).One-step fabrication of cinchona-based hybrid monolithic chiral stationary phases via photo-initiated thiol-ene polymerization for cLC enantioseparation.TALANTA,198,432-439.
MLA	Ye, Mingliang,et al."One-step fabrication of cinchona-based hybrid monolithic chiral stationary phases via photo-initiated thiol-ene polymerization for cLC enantioseparation".TALANTA 198(2019):432-439.