Methyl-Hispolon from Phellinus lonicerinus (Agaricomycetes) Affects Estrogen Signals in MCF-7 Breast Cancer Cells and Premature Aging in Rats

doi:10.1615/IntJMedMushrooms.2019030355

	Methyl-Hispolon from Phellinus lonicerinus (Agaricomycetes) Affects Estrogen Signals in MCF-7 Breast Cancer Cells and Premature Aging in Rats
	Lv, Huifang 2; Chen, Beiyan 2; Huang, Wenfeng 1; Wang, Ailing 2; Liu, Lanqing 2; He, Haibo 2,3; Wang, Junzhi 2,3; Chen, Jianfeng 2; Li, Shi 2; Deng, Wei-Qiao 2,4
刊名	INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS
	2019
卷号	21 期号:4 页码:381-392
关键词	methyl-hispolon estrogen signals phytoestrogen hormone replacement therapy Phellinus lonicerinus medicinal mushrooms
ISSN号	1521-9437
DOI	10.1615/IntJMedMushrooms.2019030355
通讯作者	Huang, Wenfeng(xyyxy1999@aliyun.com)
英文摘要	We studied Phellinus lonicerinus to determine the cytotoxic effect and the dual estrogenic activities of methyl-hispolon and their relation to estrogen signals in vivo and in vitro. The Glide scores of methyl-hispolonestrogen receptor alpha (ER alpha) and methyl-hispolon-ER beta docked complexes were -7.29 kcal/mol and -6.68 kcal/mol in docking simulations. Methyl-hispolon had a significant antiproliferative effect for estrogen-sensitive ER(+) MCF-7 cells in the absence of estrogen, and it exhibited dual estrogen activities. Methyl-hispolon increased the serum E-2 in rats with premature ovarian failure and fulfilled the estrogenic function in the uterus and ovary. Methyl-hispolon significantly inhibited the expression of Ras, AP1, ER alpha, C-myc, and cyclinD1, as well as their gene transcription in RL95-2 cells. The phosphorylation of ERK1/2 was inhibited by methyl-hispolon. Thus, methyl-hispolon has potential use in treating estrogen deficiency-related diseases, with good antitumor effects and estrogenic activity.
资助项目	National Natural Science Foundation of China[30970296] ; National Natural Science Foundation of China[31370373] ; Hubei Province Natural Science Foundation[2016CFB444]
WOS关键词	MEDICINAL MUSHROOM ; GENE-EXPRESSION ; ACTIVATION ; RECEPTOR ; LINTEUS ; APOPTOSIS ; PATHWAY
WOS研究方向	Biochemistry & Molecular Biology ; Plant Sciences ; Mycology ; Pharmacology & Pharmacy
语种	英语
出版者	BEGELL HOUSE INC
WOS记录号	WOS:000464611600007
资助机构	National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hubei Province Natural Science Foundation ; Hubei Province Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hubei Province Natural Science Foundation ; Hubei Province Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hubei Province Natural Science Foundation ; Hubei Province Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Hubei Province Natural Science Foundation ; Hubei Province Natural Science Foundation
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/165548]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Huang, Wenfeng
作者单位	1.China Three Gorges Univ, Med Coll, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Hubei, Peoples R China 2.China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Hubei Key Lab Nat Prod Res & Dev, Yichang, Hubei, Peoples R China 3.Hubei Engn Res Ctr Biol Ferment, Yichang, Hubei, Peoples R China 4.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Lv, Huifang,Chen, Beiyan,Huang, Wenfeng,et al. Methyl-Hispolon from Phellinus lonicerinus (Agaricomycetes) Affects Estrogen Signals in MCF-7 Breast Cancer Cells and Premature Aging in Rats[J]. INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS,2019,21(4):381-392.
APA	Lv, Huifang.,Chen, Beiyan.,Huang, Wenfeng.,Wang, Ailing.,Liu, Lanqing.,...&Deng, Wei-Qiao.(2019).Methyl-Hispolon from Phellinus lonicerinus (Agaricomycetes) Affects Estrogen Signals in MCF-7 Breast Cancer Cells and Premature Aging in Rats.INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS,21(4),381-392.
MLA	Lv, Huifang,et al."Methyl-Hispolon from Phellinus lonicerinus (Agaricomycetes) Affects Estrogen Signals in MCF-7 Breast Cancer Cells and Premature Aging in Rats".INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS 21.4(2019):381-392.