Changes in the morphology and protein expression of germ cells and Sertoli cells in plateau pikas testes during non-breeding season

	Changes in the morphology and protein expression of germ cells and Sertoli cells in plateau pikas testes during non-breeding season
	Liu, Ming ; Cao, Guangming ; Zhang, Yanming ; Qu, Jiapeng ; Li, Wei ; Wan, Xinrong ; Li, Yu-xia ; Zhang, Zhibin ; Wang, Yan-ling ; Gao, Fei
刊名	SCIENTIFIC REPORTS
	2016-03-04
英文摘要	Plateau pikas are seasonally breeding small herbivores that inhabit the meadow ecosystem of the Qinghai-Tibetan Plateau. Testis regression in plateau pikas begins in early June, and the male pikas are completely infertile, with a dramatically reduced testis size, in late July. In this study, a decreased germ cell number in the testes was first noted in early June. By late June, only Sertoli cells and a small number of spermatogonia remained. Interestingly, large gonocyte-like germ cells were observed in early July. In late July, the number of gonocyte-like cells per tubule increased significantly, and most of the Sertoli cell nuclei moved to and clustered in the center of the seminiferous tubules. The gonocyte-like germ cells and Sertoli cells began to express AP-2 gamma and anti-Mullerian hormone (AMH) proteins, which were detected in the germ cells and Sertoli cells of juvenile pikas but not in adult testes. Simultaneously, LC3 puncta dramatically increased in the seminiferous tubules of the pikas' testes during the nonbreeding season. Our study found that spermatogonia and Sertoli cells in non-breeding adult pikas morphologically resembled those in juvenile pikas and expressed specific markers, indicating that dedifferentiation- like transitions may occur during this process.
内容类型	期刊论文
源URL	[http://ir.nwipb.ac.cn/handle/363003/5769]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Liu, Ming,Cao, Guangming,Zhang, Yanming,et al. Changes in the morphology and protein expression of germ cells and Sertoli cells in plateau pikas testes during non-breeding season[J]. SCIENTIFIC REPORTS,2016.
APA	Liu, Ming.,Cao, Guangming.,Zhang, Yanming.,Qu, Jiapeng.,Li, Wei.,...&Gao, Fei.(2016).Changes in the morphology and protein expression of germ cells and Sertoli cells in plateau pikas testes during non-breeding season.SCIENTIFIC REPORTS.
MLA	Liu, Ming,et al."Changes in the morphology and protein expression of germ cells and Sertoli cells in plateau pikas testes during non-breeding season".SCIENTIFIC REPORTS (2016).