Molecular Basis of Overdominance at a Flower Color Locus

	Molecular Basis of Overdominance at a Flower Color Locus
	LaFountain, Amy M. ; Chen, Wenjie ; Sun, Wei ; Chen, Shilin ; Frank, Harry A. ; Ding, Baoqing ; Yuan, Yao-Wu
刊名	G3-GENES GENOMES GENETICS
	2017-12-01
英文摘要	Single-gene overdominance is one of the major mechanisms proposed to explain heterosis (i.e., hybrid vigor), the phenomenon that hybrid offspring between two inbred lines or varieties show superior phenotypes to both parents. Although sporadic examples of single-gene overdominance have been reported over the decades, the molecular nature of this phenomenon remains poorly understood and it is unclear whether any generalizable principle underlies the various cases. Through bulk segregant analysis, chemical profiling, and transgenic experiments, we show that loss-of-function alleles of the FLAVONE SYNTHASE (FNS) gene cause overdominance in anthocyanin-based flower color intensity in the monkey-flower species Mimulus lewisii. FNS negatively affects flower color intensity by competing with the anthocyanin biosynthetic enzymes for the same substrates, yet positively affects flower color intensity by producing flavones, the colorless copigments required for anthocyanin stabilization, leading to enhanced pigmentation in the heterozyote (FNS/fns) relative to both homozygotes (FNS/FNS and fns/fns). We suggest that this type of antagonistic pleiotropy (i.e., alleles with opposing effects on different components of the phenotypic output) might be a general principle underlying single-gene overdominance.
内容类型	期刊论文
源URL	[http://ir.nwipb.ac.cn/handle/363003/13276]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	LaFountain, Amy M.,Chen, Wenjie,Sun, Wei,et al. Molecular Basis of Overdominance at a Flower Color Locus[J]. G3-GENES GENOMES GENETICS,2017.
APA	LaFountain, Amy M..,Chen, Wenjie.,Sun, Wei.,Chen, Shilin.,Frank, Harry A..,...&Yuan, Yao-Wu.(2017).Molecular Basis of Overdominance at a Flower Color Locus.G3-GENES GENOMES GENETICS.
MLA	LaFountain, Amy M.,et al."Molecular Basis of Overdominance at a Flower Color Locus".G3-GENES GENOMES GENETICS (2017).