Daily chemical evodiamine from Chinese prickly ash attenuates osteoclast differentiation through RANKL induced NFAT pathways

	Daily chemical evodiamine from Chinese prickly ash attenuates osteoclast differentiation through RANKL induced NFAT pathways
	Jiang, Lei ; Zhao, Xiaoying ; Pei, Jinjin ; Mei, Lijuan ; Cui, Yulei ; Wang, Shuo ; Shao, Yun ; Zhang, Xiaoling ; Tao, Yanduo
刊名	JOURNAL OF FUNCTIONAL FOODS
	2017-10-01
英文摘要	Osteoclasts (OCs) play an important role in a variety of lytic bone diseases. New bone protective therapies exploration has been focused on the suppression of OC formation. In this study, we report that daily chemical evodiamine from Chinese prickly ash, a very common sauce used for stewing meats, attenuates RANKL-induced OC formation, the expression level of OC-specific marker genes and OC marker protein in vitro. Mechanistically, evodiamine dose- and time-dependently blocked the RANKL-induced activation of ERK and c-Fos as well as the induction of NFATc1, which is essential for OC formation. These data suggest that evodiamine might be a useful alternative therapy in preventing or treating osteolytic diseases. (C) 2017 Elsevier Ltd. All rights reserved.
内容类型	期刊论文
源URL	[http://ir.nwipb.ac.cn/handle/363003/9828]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Jiang, Lei,Zhao, Xiaoying,Pei, Jinjin,et al. Daily chemical evodiamine from Chinese prickly ash attenuates osteoclast differentiation through RANKL induced NFAT pathways[J]. JOURNAL OF FUNCTIONAL FOODS,2017.
APA	Jiang, Lei.,Zhao, Xiaoying.,Pei, Jinjin.,Mei, Lijuan.,Cui, Yulei.,...&Tao, Yanduo.(2017).Daily chemical evodiamine from Chinese prickly ash attenuates osteoclast differentiation through RANKL induced NFAT pathways.JOURNAL OF FUNCTIONAL FOODS.
MLA	Jiang, Lei,et al."Daily chemical evodiamine from Chinese prickly ash attenuates osteoclast differentiation through RANKL induced NFAT pathways".JOURNAL OF FUNCTIONAL FOODS (2017).