Mercury sulfides are much less nephrotoxic than mercury chloride and methylmercury in mice

	Mercury sulfides are much less nephrotoxic than mercury chloride and methylmercury in mice
	Liu, Jie ; Lu, Yuan-Fu ; Li, Wen-Kai ; Zhou, Zheng-Ping ; Li, Ying-Ying ; Yang, Xi ; Li, Cen ; Du, Yu-Zhi ; Wei, Li-Xin
刊名	TOXICOLOGY LETTERS
	2016-11-16
英文摘要	Mercury sulfides (alpha-HgS, beta-HgS) are frequently included in traditional medicines. Mercury is known for nephrotoxicity, their safety is of concern. To address this question, mice were orally administrated with Zuotai (54% beta-HgS, 30 mg/kg), alpha-HgS (HgS, 30 mg/kg), HgCl2 (33.6 mg/kg), or MeHgCl (3.1 mg/kg) for 7 days, and nephrotoxicity was examined. Animal body weights were decreased by HgCl2 and to a lesser extent by MeHg, but unaltered after Zuotai and HgS. HgCl2 and MeHg produced renal tubular vacuolation, interstitial inflammation and cell degeneration with protein cysts in the tubular lumen, while these pathological lesions were mild in Zuotai and HgS-treated mice. Electron microscopy showed that HgCl2 and MeHg produced spotted swelling endothelium reticulum, while these lesions were mild or absent in Zuotai and HgS-treated mice. Renal Hg contents reached 250-300 ng/mg kidney in HgCl2 and MeHg groups as compared to 2-3 ng/mg in Zuotai and HgS groups. The expression of kidney injury biomarkers, kidney injury molecule-1 (Kim-1) and neutrophil gelatinase-associated lipocalin (Ngal), were increased after HgCl2 and MeHg, but unaltered after Zuotai and HgS. The expression of renal influx transporters Oat3 and Oatp4c1 was decreased, while the expression of renal efflux transporter such as Mrp2, Mrp4, and Mate2 was increased following HgCl2 and MeHg. These gene expressions were unchanged after Zuotai and HgS. In summary, both alpha-HgS and beta-HgS are less nephrotoxic than HgCl2 and MeHg, indicating that chemical forms of mercury are a major determinant of mercury disposition and toxicity. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
内容类型	期刊论文
源URL	[http://ir.nwipb.ac.cn/handle/363003/6420]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Liu, Jie,Lu, Yuan-Fu,Li, Wen-Kai,et al. Mercury sulfides are much less nephrotoxic than mercury chloride and methylmercury in mice[J]. TOXICOLOGY LETTERS,2016.
APA	Liu, Jie.,Lu, Yuan-Fu.,Li, Wen-Kai.,Zhou, Zheng-Ping.,Li, Ying-Ying.,...&Wei, Li-Xin.(2016).Mercury sulfides are much less nephrotoxic than mercury chloride and methylmercury in mice.TOXICOLOGY LETTERS.
MLA	Liu, Jie,et al."Mercury sulfides are much less nephrotoxic than mercury chloride and methylmercury in mice".TOXICOLOGY LETTERS (2016).