Molecular Basis of Overdominance at a Flower Color Locus

doi:10.1534/g3.117.300336

	Molecular Basis of Overdominance at a Flower Color Locus
	Yuan, Yao-Wu 5; Ding, Baoqing 5; Frank, Harry A.4; Chen, Shilin 1; Sun, Wei 1; Chen, Wenjie 2,3,5; LaFountain, Amy M.4,5
刊名	G3-GENES GENOMES GENETICS
	2017-12-01
卷号	7 期号:12 页码:3947-3954
关键词	Heterosis Mimulus Flavone Synthase Antagonistic Pleiotropy Anthocyanins
ISSN号	2160-1836
DOI	10.1534/g3.117.300336
文献子类	Article
英文摘要	Single-gene overdominance is one of the major mechanisms proposed to explain heterosis (i.e., hybrid vigor), the phenomenon that hybrid offspring between two inbred lines or varieties show superior phenotypes to both parents. Although sporadic examples of single-gene overdominance have been reported over the decades, the molecular nature of this phenomenon remains poorly understood and it is unclear whether any generalizable principle underlies the various cases. Through bulk segregant analysis, chemical profiling, and transgenic experiments, we show that loss-of-function alleles of the FLAVONE SYNTHASE (FNS) gene cause overdominance in anthocyanin-based flower color intensity in the monkey-flower species Mimulus lewisii. FNS negatively affects flower color intensity by competing with the anthocyanin biosynthetic enzymes for the same substrates, yet positively affects flower color intensity by producing flavones, the colorless copigments required for anthocyanin stabilization, leading to enhanced pigmentation in the heterozyote (FNS/fns) relative to both homozygotes (FNS/FNS and fns/fns). We suggest that this type of antagonistic pleiotropy (i.e., alleles with opposing effects on different components of the phenotypic output) might be a general principle underlying single-gene overdominance.
WOS关键词	MIMULUS-LEWISII ; INDUCED MUTATIONS ; HETEROSIS ; ANTHOCYANIN ; HYBRID ; GENE ; PIGMENTATION ; TOMATO ; MAIZE
WOS研究方向	Genetics & Heredity
语种	英语
出版者	GENETICS SOCIETY AMERICA
WOS记录号	WOS:000417073900011
资助机构	University of Connecticut ; National Science Foundation(IOS-1558083) ; University of Connecticut Research Foundation
内容类型	期刊论文
源URL	[http://ir.nwipb.ac.cn/handle/363003/13276]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
通讯作者	Yuan, Yao-Wu
作者单位	1.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China 2.Key Lab Crop Mol Breeding Qinghai Prov, Xining 810008, Qinghai, Peoples R China 3.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining, Qinghai, Peoples R China 4.Univ Connecticut, Dept Chem, Storrs, CT 06269 USA 5.Univ Connecticut, Dept Ecol & Evolutionary Biol, 75 N Eagleville Rd,Unit 3043, Storrs, CT 06269 USA
推荐引用方式 GB/T 7714	Yuan, Yao-Wu,Ding, Baoqing,Frank, Harry A.,et al. Molecular Basis of Overdominance at a Flower Color Locus[J]. G3-GENES GENOMES GENETICS,2017,7(12):3947-3954.
APA	Yuan, Yao-Wu.,Ding, Baoqing.,Frank, Harry A..,Chen, Shilin.,Sun, Wei.,...&LaFountain, Amy M..(2017).Molecular Basis of Overdominance at a Flower Color Locus.G3-GENES GENOMES GENETICS,7(12),3947-3954.
MLA	Yuan, Yao-Wu,et al."Molecular Basis of Overdominance at a Flower Color Locus".G3-GENES GENOMES GENETICS 7.12(2017):3947-3954.