EVALUATION OF THE ANTITUMOR ACTIVITY BY CdTe QDs WITH VERBASCOSIDE

	EVALUATION OF THE ANTITUMOR ACTIVITY BY CdTe QDs WITH VERBASCOSIDE
	Zhao, Xiao-Hui ; Yue, Hui-Lan ; Li, Ping ; Zeng, Xin ; Zhang, Gen ; Zeng, X (reprint author), Nanjing Med Univ, Nanjing Matern & Child Hlth Care Hosp, State Key Lab Reprod Med, Dept Gynecol Endocrine, Nanjing 210029, Jiangsu, Peoples R China.
刊名	NANO ; Zhao, XH; Yue, HL; Li, P; Zeng, X; Zhang, G.EVALUATION OF THE ANTITUMOR ACTIVITY BY CdTe QDs WITH VERBASCOSIDE,NANO,2013,8(3):
	2013-06-01
英文摘要	Cadmium telluride quantum dots (QDs) have received significant attention in biomedical research because of their potential in drug delivery. In this study, the chemotherapeutic agent Verbascoside (VB) was immobilized successfully onto CdTe QDs by covalent bonding between the -OH group of VB and the -COOH group of CdTe QDs. The amount of VB that could be immobilized depended on the concentration of -COOH groups (succinic acid) on the surface of the CdTe QDs. Apoptotic staining, DNA fragmentation and flow cytometry analysis further demonstrated that compared with CdTe QDs or VB treatment alone, the apoptosis rate increased after the treatment of CdTe QDs together with VB (VB-QDs) in HepG2/ADM cells. We observed that VB-QDs treatment could clearly activate apoptosis-related Caspase 3 expression in HepG2/ADM cells. Moreover, our in vivo study indicated that the treatment of VB-QDs effectively inhibited the human hepatoma HepG2/ADM nude mice tumor growth. The increased cell apoptosis rate was closely correlated with the enhanced inhibition of tumor growth in the studied animals. Thus, VB-QDs may serve as a possible alternative for therapeutic approaches for some cancer treatments. In summary, studies have shown that cancer cells are treated by the presence of VB-QDs nanoparticles based on analysis of cell apoptosis.; Cadmium telluride quantum dots (QDs) have received significant attention in biomedical research because of their potential in drug delivery. In this study, the chemotherapeutic agent Verbascoside (VB) was immobilized successfully onto CdTe QDs by covalent bonding between the -OH group of VB and the -COOH group of CdTe QDs. The amount of VB that could be immobilized depended on the concentration of -COOH groups (succinic acid) on the surface of the CdTe QDs. Apoptotic staining, DNA fragmentation and flow cytometry analysis further demonstrated that compared with CdTe QDs or VB treatment alone, the apoptosis rate increased after the treatment of CdTe QDs together with VB (VB-QDs) in HepG2/ADM cells. We observed that VB-QDs treatment could clearly activate apoptosis-related Caspase 3 expression in HepG2/ADM cells. Moreover, our in vivo study indicated that the treatment of VB-QDs effectively inhibited the human hepatoma HepG2/ADM nude mice tumor growth. The increased cell apoptosis rate was closely correlated with the enhanced inhibition of tumor growth in the studied animals. Thus, VB-QDs may serve as a possible alternative for therapeutic approaches for some cancer treatments. In summary, studies have shown that cancer cells are treated by the presence of VB-QDs nanoparticles based on analysis of cell apoptosis.
内容类型	期刊论文
源URL	[http://ir.nwipb.ac.cn/handle/363003/3938]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Zhao, Xiao-Hui,Yue, Hui-Lan,Li, Ping,et al. EVALUATION OF THE ANTITUMOR ACTIVITY BY CdTe QDs WITH VERBASCOSIDE[J]. NANO, Zhao, XH; Yue, HL; Li, P; Zeng, X; Zhang, G.EVALUATION OF THE ANTITUMOR ACTIVITY BY CdTe QDs WITH VERBASCOSIDE,NANO,2013,8(3):,2013.
APA	Zhao, Xiao-Hui,Yue, Hui-Lan,Li, Ping,Zeng, Xin,Zhang, Gen,&Zeng, X .(2013).EVALUATION OF THE ANTITUMOR ACTIVITY BY CdTe QDs WITH VERBASCOSIDE.NANO.
MLA	Zhao, Xiao-Hui,et al."EVALUATION OF THE ANTITUMOR ACTIVITY BY CdTe QDs WITH VERBASCOSIDE".NANO (2013).