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	In silico characterization of the functional and structural modules of the hemagglutinin protein from the swine-origin influenza virus a (h1n1)-2009
	Sun YePing1,2,3; Shi Yi1,2,3; Zhang Wei1,2,3; Li Qing1,2,3,4; Liu Di1; Vavricka, Christopher1; Yan JingHua1,3; Gao, George F.1,2,3,5
刊名	Science china-life sciences
	2010-06-01
卷号	53期号:6页码:633-642
关键词	2009 s-oiv Hemagglutinin In silico Structural and functional modules
ISSN号	1674-7305
DOI	10.1007/s11427-010-4010-8
通讯作者	Gao, george f.(gaof@im.ac.cn)
英文摘要	The 2009 swine-origin influenza virus (s-oiv, h1n1 subtype) has developed into a new pandemic influenza as announced by the world health organization. in order to uncover clues about the determinants for virulence and pathogenicity of the virus, we characterized the functional modules of the surface glycoprotein hemagglutinin (ha), the most important protein in molecular epidemiology and pathogenesis of influenza viruses. we analyzed receptor binding sites, basic patch, neutralization antibody epitopes and t cell epitopes in the ha protein of the current s-oiv according to the corresponding functional and structural modules previously characterized in other h1 ha molecules or ha molecules of other subtypes. we compared their differences and similarities systematically. based on the amino acids defined as the functional and structural modules, the ha protein of 2009 s-oiv should specifically bind to the human 2,6-receptor. the d225g/e mutation in ha, which is found in some isolates, may confer dual binding specificity to the 2,3- and 2,6-receptor based on previously reported work. this ha variant contains two basic patches, one of which results in increased basicity, suggesting enhanced membrane fusion function. the 2009 s-oiv ha also has an extra glycosylation site at position 276. four of the five antibody neutralization epitopes identified in a/rp/8/34(h1n1) were exposed, but the other was hidden by a glycosylation site. the previously identified cytotoxic t cell epitopes in various ha molecules were summarized and their corresponding sequences in 2009 s-oiv ha were defined. these results are critical for understanding the pathogenicity of the virus and host immune response against the virus.
WOS关键词	RECEPTOR-BINDING PROPERTIES ; A H1N1 VIRUS ; MEMBRANE-FUSION ; CTL EPITOPES ; RECOGNITION ; H5N1 ; ANTIBODY ; SPECIFICITY ; COMPLEX ; SITE
WOS研究方向	Life Sciences & Biomedicine - Other Topics
WOS类目	Biology
语种	英语
出版者	SCIENCE PRESS
WOS记录号	WOS:000279506400001
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2415232
专题	中国科学院大学
通讯作者	Gao, George F.
作者单位	1.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Microbiol, China Japan Joint Lab Mol Immunol & Mol Microbiol, Beijing 100101, Peoples R China 4.Univ Sci & Technol China, Coll Life Sci, Hefei 230027, Peoples R China 5.Chinese Acad Sci, Beijing Inst Life Sci, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Sun YePing,Shi Yi,Zhang Wei,et al. In silico characterization of the functional and structural modules of the hemagglutinin protein from the swine-origin influenza virus a (h1n1)-2009[J]. Science china-life sciences,2010,53(6):633-642.
APA	Sun YePing.,Shi Yi.,Zhang Wei.,Li Qing.,Liu Di.,...&Gao, George F..(2010).In silico characterization of the functional and structural modules of the hemagglutinin protein from the swine-origin influenza virus a (h1n1)-2009.Science china-life sciences,53(6),633-642.
MLA	Sun YePing,et al."In silico characterization of the functional and structural modules of the hemagglutinin protein from the swine-origin influenza virus a (h1n1)-2009".Science china-life sciences 53.6(2010):633-642.

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