| Meta-analysis of vitamin d, calcium and the prevention of breast cancer | |
| Chen, Peizhan1,2; Hu, Pingting1,2; Xie, Dong1,2; Qin, Ying1,2; Wang, Fudi1,2; Wang, Hui1,2 | |
| 刊名 | Breast cancer research and treatment
 |
| 2010-06-01 | |
| 卷号 | 121期号:2页码:469-477 |
| 关键词 | Vitamin d 25(oh)d 1 alpha,25(oh)(2)d Calcium Breast cancer Meta-analysis |
| ISSN号 | 0167-6806 |
| DOI | 10.1007/s10549-009-0593-9 |
| 通讯作者 | Wang, hui(huiwang@sibs.ac.cn) |
| 英文摘要 | Vitamin d and calcium intake have been suggested to have protective effects against breast cancer; however, the data have been inconclusive. the present meta-analysis examined the overall effects of vitamin d intake, circulating 25(oh) d and 1 alpha,25(oh)(2)d levels, and calcium intake on breast cancer risk. data from 11 studies on vitamin d intake, 7 studies on circulating 25(oh) d levels, 3 studies of circulating 1 alpha,25(oh)(2)d levels, and 15 studies on calcium intake and breast cancer risk were included in this analysis. from the meta-analysis, there was a significant inverse relationship between vitamin d intake and breast cancer risk, with an overall relative risk (rr) of high versus low vitamin d intake for breast cancer of 0.91 (95% ci = 0.85-0.97). the highest quantile of circulating 25(oh) d was found to be associated with a 45% (or = 0.55, 95% ci = 0.38-0.80) decrease in breast cancer when compared with the lowest quantile. no significant association for the circulating 1a, 25(oh)(2)d level and breast cancer was found (or = 0.99, 95% ci = 0.68-1.44). for calcium, a 19% (rr = 0.81, 95% ci = 0.72-0.90) decrease in breast cancer risk was found for those with highest quantile of calcium intake compared to the lowest quantile. these results provide strong evidence that vitamin d and calcium have a chemopreventive effect against breast cancer. |
| WOS关键词 | PLASMA 25-HYDROXYVITAMIN D ; DIETARY CALCIUM ; DAIRY-PRODUCTS ; CELL-PROLIFERATION ; D SUPPLEMENTATION ; PUBLICATION BIAS ; RISK ; WOMEN ; MICRONUTRIENTS ; HYPOTHESIS |
| WOS研究方向 | Oncology |
| WOS类目 | Oncology |
| 语种 | 英语 |
| 出版者 | SPRINGER |
| WOS记录号 | WOS:000277906500023 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2413649 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, Hui |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Nutr & Metab, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Grad Sch, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Peizhan,Hu, Pingting,Xie, Dong,et al. Meta-analysis of vitamin d, calcium and the prevention of breast cancer[J]. Breast cancer research and treatment,2010,121(2):469-477. |
| APA | Chen, Peizhan,Hu, Pingting,Xie, Dong,Qin, Ying,Wang, Fudi,&Wang, Hui.(2010).Meta-analysis of vitamin d, calcium and the prevention of breast cancer.Breast cancer research and treatment,121(2),469-477. |
| MLA | Chen, Peizhan,et al."Meta-analysis of vitamin d, calcium and the prevention of breast cancer".Breast cancer research and treatment 121.2(2010):469-477. |
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