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	Exploring mitochondrial evolution and metabolism organization principles by comparative analysis of metabolic networks
	Chang, Xiao1,2,3; Wang, Zhuo4; Hao, Pei1,2; Li, Yuan-Yuan1,2; Li, Yi-Xue1,2
刊名	Genomics
	2010-06-01
卷号	95期号:6页码:339-344
关键词	Metabolic network Betweenness centrality Degree centrality Triad significance profiles
ISSN号	0888-7543
DOI	10.1016/j.ygeno.2010.03.006
通讯作者	Li, yuan-yuan(yyli@scbit.org)
英文摘要	The endosymbiotic theory proposed that mitochondrial genomes are derived from an alpha-proteobacterium-like endosymbiont, which was concluded from sequence analysis. we rebuilt the metabolic networks of mitochondria and 22 relative species, and studied the evolution of mitochondrial metabolism at the level of enzyme content and network topology. our phylogenetic results based on network alignment and motif identification supported the endosymbiotic theory from the point of view of systems biology for the first time. it was found that the mitochondrial metabolic network were much more compact than the relative species, probably related to the higher efficiency of oxidative phosphorylation of the specialized organelle, and the network is highly clustered around the tca cycle. moreover, the mitochondrial metabolic network exhibited high functional specificity to the modules. this work provided insight to the understanding of mitochondria evolution, and the organization principle of mitochondrial metabolic network at the network level. (c) 2010 elsevier inc. all rights reserved.
WOS关键词	SYSTEMS BIOLOGY ; COMPLEX NETWORKS ; GENOME-SCALE ; RECONSTRUCTION ; ORIGIN ; ORGANISMS ; BACTERIA ; MOTIFS ; PROTEOME ; ENZYMES
WOS研究方向	Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS类目	Biotechnology & Applied Microbiology ; Genetics & Heredity
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000278341600003
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2413586
专题	中国科学院大学
通讯作者	Li, Yuan-Yuan
作者单位	1.Shanghai Ctr Bioinformat Technol, Shanghai 200235, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Bioinformat Ctr, Key Lab Syst Biol, Shanghai 200031, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 4.Shanghai Jiao Tong Univ, Coll Life Sci & Biotechnol, Shanghai 200240, Peoples R China
推荐引用方式 GB/T 7714	Chang, Xiao,Wang, Zhuo,Hao, Pei,et al. Exploring mitochondrial evolution and metabolism organization principles by comparative analysis of metabolic networks[J]. Genomics,2010,95(6):339-344.
APA	Chang, Xiao,Wang, Zhuo,Hao, Pei,Li, Yuan-Yuan,&Li, Yi-Xue.(2010).Exploring mitochondrial evolution and metabolism organization principles by comparative analysis of metabolic networks.Genomics,95(6),339-344.
MLA	Chang, Xiao,et al."Exploring mitochondrial evolution and metabolism organization principles by comparative analysis of metabolic networks".Genomics 95.6(2010):339-344.

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