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	Pore-like aggregates of tau protein induced by formaldehyde
	Naqvi, Sajjad Haider1,2; Wang Wei-Shan3; Miao Jun-Ye1,2; He Rong-Qiao1,2
刊名	Progress in biochemistry and biophysics
	2010-11-01
卷号	37期号:11页码:1195-1203
关键词	Tau protein Formaldehyde Misfolding Pore-like aggregates Neurodegeneration Chronic impairment Sporadic alzheimer's diseases
ISSN号	1000-3282
DOI	10.3724/sp.j.1206.2010.00375
通讯作者	He rong-qiao()
英文摘要	Though the hypothesis of "aspecific amyloid ion channels" has been proposed by lin, et at (university of california, santa barbara) to explain the mechanism of metabolic dysfunction and cell death during protein conformational diseases, the "pore-like" aggregates of misfolded neural tau have not been observed revulsants involved in the formation of "pore-like" aggregates have not been found yet according to the hypothesis "chronic impairment resulted from abnormally-increased endogenous formaldehyde is one of the important risk factors related to sporadic senile dementia", formaldehyde has been utilized to incubate with tau protein resulting in amyloid-like deposits with marked cytotoxicity under the experimental conditions, 0 5% formaldehyde-treated tau could form "pore-like" aggregates these results may deliver a novel approach to study the mechanism of cellular metabolic disturbance, even cell death, which is induced by formaldehyde-treated neural tau
WOS关键词	DISEASE ; NEURODEGENERATION ; CONFORMATION ; TUBULIN
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS类目	Biochemistry & Molecular Biology ; Biophysics
语种	英语
出版者	CHINESE ACAD SCIENCES, INST BIOPHYSICS
WOS记录号	WOS:000284722900005
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2412639
专题	中国科学院大学
通讯作者	He Rong-Qiao
作者单位	1.Chinese Acad Sci, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Beijing Hosp Elderly, Beijing 100095, Peoples R China
推荐引用方式 GB/T 7714	Naqvi, Sajjad Haider,Wang Wei-Shan,Miao Jun-Ye,et al. Pore-like aggregates of tau protein induced by formaldehyde[J]. Progress in biochemistry and biophysics,2010,37(11):1195-1203.
APA	Naqvi, Sajjad Haider,Wang Wei-Shan,Miao Jun-Ye,&He Rong-Qiao.(2010).Pore-like aggregates of tau protein induced by formaldehyde.Progress in biochemistry and biophysics,37(11),1195-1203.
MLA	Naqvi, Sajjad Haider,et al."Pore-like aggregates of tau protein induced by formaldehyde".Progress in biochemistry and biophysics 37.11(2010):1195-1203.

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