| Variations in/nearby genes coding for jazf1, tspan8/lgr5 and hhex-ide and risk of type 2 diabetes in han chinese | |
| Zhou, Dai-zhan2; Liu, Yun3; Zhang, Di2; Liu, Si-min4,5,6; Yu, Lan2,7; Yang, Yi-feng2; Zhao, Teng2; Chen, Zhuo2; Kan, Meng-yuan2; Zhang, Zuo-feng4 | |
| 刊名 | Journal of human genetics
 |
| 2010-12-01 | |
| 卷号 | 55期号:12页码:810-815 |
| 关键词 | Association study Han chinese population Hhex Type 2 diabetes |
| ISSN号 | 1434-5161 |
| DOI | 10.1038/jhg.2010.117 |
| 通讯作者 | Xu, he(hexu@ucla.edu) |
| 英文摘要 | Several genetic loci (jazf1, cdc123/camk1d, tspan8/lgr5, adamts9, vegfa and hhex-ide) were identified to be significantly related to the risk of type 2 diabetes and quantitative metabolic traits in european populations. here, we aimed to evaluate the impacts of these novel loci on type 2 diabetes risk in a population-based case-control study of han chinese (1912 cases and 2041 controls). we genotyped 13 single-nucleotide polymorphisms (snps) in/near these genes and examined the differences in allele/genotype frequency between cases and controls. we found that both ide rs11187007 and hhex rs1111875 were associated with type 2 diabetes risk (for both variants: odds ratio (or)=1.15, 95% confidence interval (ci) 1.04-1.28, p=0.009). in a meta-analysis where we pooled our data with the three previous studies conducted in east asians, we found that the variants of jazf1 rs864745 (1.09 (1.03-1.16); p=3.49x10(-3)) and tspan8/lgr5 rs7961581 (1.11 (1.05-1.17); p=1.89x10(-4)) were significantly associated with type 2 diabetes risk. in addition, the meta-analysis (7207 cases and 8260 controls) also showed that hhex rs1111875 did have effects on type 2 diabetes in chinese population (or=1.15(1.10-1.21); p=1.93x10(-8)). this large population-based study and meta-analysis further confirmed the modest effects of the jazf1, tspan8/lgr5 and hhex-ide loci on type 2 diabetes in chinese and other east asians. journal of human genetics (2010) 55, 810-815; doi:10.1038/jhg.2010.117; published online 7 october 2010 |
| WOS关键词 | GENOME-WIDE ASSOCIATION ; INSULIN SENSITIVITY ; SUSCEPTIBILITY LOCI ; JAPANESE POPULATION ; POLYMORPHISMS ; CDKAL1 ; GLUCOSE ; REPLICATION ; VARIANTS ; CDKN2A/B |
| WOS研究方向 | Genetics & Heredity |
| WOS类目 | Genetics & Heredity |
| 语种 | 英语 |
| 出版者 | NATURE PUBLISHING GROUP |
| WOS记录号 | WOS:000285545000006 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2412472 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Xu, He |
| 作者单位 | 1.Chinese Acad Sci, Inst Nutr Sci, Shanghai Inst Biol Sci, Grad Sch, Shanghai 200031, Peoples R China 2.Shanghai Jiao Tong Univ, Minist Educ, Key Lab Dev Genet & Neuropsychiat Dis, Bio X Ctr, Shanghai 200030, Peoples R China 3.Fudan Univ, Inst Biomed Sci, Shanghai 200433, Peoples R China 4.Univ Calif Los Angeles, Dept Epidemiol, Los Angeles, CA USA 5.Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA 6.Univ Calif Los Angeles, Ctr Metab Dis Prevent, Los Angeles, CA USA 7.Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA |
| 推荐引用方式 GB/T 7714 | Zhou, Dai-zhan,Liu, Yun,Zhang, Di,et al. Variations in/nearby genes coding for jazf1, tspan8/lgr5 and hhex-ide and risk of type 2 diabetes in han chinese[J]. Journal of human genetics,2010,55(12):810-815. |
| APA | Zhou, Dai-zhan.,Liu, Yun.,Zhang, Di.,Liu, Si-min.,Yu, Lan.,...&He, Lin.(2010).Variations in/nearby genes coding for jazf1, tspan8/lgr5 and hhex-ide and risk of type 2 diabetes in han chinese.Journal of human genetics,55(12),810-815. |
| MLA | Zhou, Dai-zhan,et al."Variations in/nearby genes coding for jazf1, tspan8/lgr5 and hhex-ide and risk of type 2 diabetes in han chinese".Journal of human genetics 55.12(2010):810-815. |
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