| Microrna-101 targets mapk phosphatase-1 to regulate the activation of mapks in macrophages | |
| Zhu, Qing-Yuan1,2; Liu, Qin3; Chen, Jian-Xia1; Lan, Ke1; Ge, Bao-Xue1,3 | |
| 刊名 | Journal of immunology
 |
| 2010-12-15 | |
| 卷号 | 185期号:12页码:7435-7442 |
| ISSN号 | 0022-1767 |
| DOI | 10.4049/jimmunol.1000798 |
| 通讯作者 | Ge, bao-xue(gebaoxue@sibs.ac.cn) |
| 英文摘要 | Mapk phosphatase-1 (mkp-1) is an archetypical member of the dual-specificity phosphatase family that deactivates mapks. induction of mkp-1 has been implicated in attenuating the lps- or peptidoglycan-induced biosynthesis of proinflammatory cytokines, but the role of noncoding rna in the expression of the mkp-1 is still poorly understood. in this study, we show that mkp-1 is a direct target of microrna-101 (mir-101). transfection of mir-101 attenuates induction of mkp-1 by lps as well as prolonged activation of p38 and jnk/stress-activated protein kinase, whereas inhibition of mir-101 enhances the expression of mkp-1 and shortens p38 and jnk activation. we also found that expression of mir-101 is induced by multiple tlr ligands, including lps, peptidoglycan, or polyinosinic-polycytidylic acid, and that inhibition of pi3k/akt by ly294002 or akt rna interference blocks the induction of mir-101 by lps in raw264.7 macrophage cells. moreover, treatment of cells with dexamethasone, a widely used anti-inflammatory agent, markedly inhibits mir-101 expression and enhances the expression of mkp-1 in lps-stimulated macrophages. together, these results indicate that mir-101 regulates the innate immune responses of macrophages to lps through targeting mkp-1. the journal of immunology, 2010, 185: 7435-7442. |
| WOS关键词 | INNATE IMMUNE-RESPONSES ; LIPOPOLYSACCHARIDE-DEPENDENT ACTIVATION ; PROTEIN-KINASE PHOSPHATASE-1 ; ENDOTOXIN-SHOCK ; DOWN-REGULATION ; EXPRESSION ; CELLS ; MKP-1 ; INDUCTION ; CANCER |
| WOS研究方向 | Immunology |
| WOS类目 | Immunology |
| 语种 | 英语 |
| 出版者 | AMER ASSOC IMMUNOLOGISTS |
| WOS记录号 | WOS:000284878700040 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2410300 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Ge, Bao-Xue |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Chinese Acad Sci, Sch Med, Inst Pasteur Shanghai, Shanghai 200025, Peoples R China 2.Shanghai Jiao Tong Univ, Chinese Acad Sci, Sch Med, Grad Sch, Shanghai 200025, Peoples R China 3.Shanghai Jiao Tong Univ, Chinese Acad Sci, Key Lab Stem Cell Biol, Inst Hlth Sci,Shanghai Inst Biol Sci,Sch Med, Shanghai 200025, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Qing-Yuan,Liu, Qin,Chen, Jian-Xia,et al. Microrna-101 targets mapk phosphatase-1 to regulate the activation of mapks in macrophages[J]. Journal of immunology,2010,185(12):7435-7442. |
| APA | Zhu, Qing-Yuan,Liu, Qin,Chen, Jian-Xia,Lan, Ke,&Ge, Bao-Xue.(2010).Microrna-101 targets mapk phosphatase-1 to regulate the activation of mapks in macrophages.Journal of immunology,185(12),7435-7442. |
| MLA | Zhu, Qing-Yuan,et al."Microrna-101 targets mapk phosphatase-1 to regulate the activation of mapks in macrophages".Journal of immunology 185.12(2010):7435-7442. |
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