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	Whole genome sequencing of lamb rotavirus and comparative analysis with other mammalian rotaviruses
	Chen, Yanjun1,2; Zhu, Weiwen3; Sui, Shuo1; Yin, Yuxin1; Hu, Songnian1; Zhang, Xiaowei1
刊名	Virus genes
	2009-04-01
卷号	38期号:2页码:302-310
关键词	Rotavirus Genome Genotyping Phylogenetic analysis Comparative analysis
ISSN号	0920-8569
DOI	10.1007/s11262-009-0332-7
通讯作者	Hu, songnian(husn@big.ac.cn)
英文摘要	Rotavirus (rv) epidemiological surveys with molecular analysis of various strains are required for gastroenteritis control and prevention. the lamb rotavirus strain nt, isolated from a diarrhea lamb in china, is considered as a promising vaccine strain. the whole genome of the lamb-nt strain was determined by sequence analysis. sequence identity and phylogenetic analysis defined the lamb-nt strain as group a, genotype g10p[15]/nsp4[a]/sg1 strain. comparative genomic analysis of the lamb-nt strain and 17 reference strains reveals that gene reassortments between rotaviruses circulating in different species occurred. alignment of protein sequences of the genes shows some variations in the important functional regions of vp3 and vp4. these variations are related to host range restriction, virulence, and other potential characters of rotaviruses. besides, this study also makes a significant foundation for the study of genetic classification, epidemiology, and antigenic diversity of rotaviruses on the molecular level.
WOS关键词	GROUP-A ROTAVIRUS ; COMPLETE NUCLEOTIDE-SEQUENCE ; AMINO-ACID-SEQUENCE ; GUANYLYLTRANSFERASE ACTIVITY ; MOLECULAR CHARACTERIZATION ; MIXED INFECTIONS ; VACCINE ; CHILDREN ; EFFICACY ; INFANTS
WOS研究方向	Genetics & Heredity ; Virology
WOS类目	Genetics & Heredity ; Virology
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000263900500015
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2404591
专题	中国科学院大学
通讯作者	Hu, Songnian
作者单位	1.Chinese Acad Sci, Beijing Inst Genom, Key Lab Genom Sci & Informat, Beijing 100029, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Beijing Natcare Biotech Co L, Beijing 10008, Peoples R China
推荐引用方式 GB/T 7714	Chen, Yanjun,Zhu, Weiwen,Sui, Shuo,et al. Whole genome sequencing of lamb rotavirus and comparative analysis with other mammalian rotaviruses[J]. Virus genes,2009,38(2):302-310.
APA	Chen, Yanjun,Zhu, Weiwen,Sui, Shuo,Yin, Yuxin,Hu, Songnian,&Zhang, Xiaowei.(2009).Whole genome sequencing of lamb rotavirus and comparative analysis with other mammalian rotaviruses.Virus genes,38(2),302-310.
MLA	Chen, Yanjun,et al."Whole genome sequencing of lamb rotavirus and comparative analysis with other mammalian rotaviruses".Virus genes 38.2(2009):302-310.

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