| The retromer component snx6 interacts with dynactin p150(glued) and mediates endosome-to-tgn transport | |
| Hong, Zhi1,2; Yang, Yanrui1; Zhang, Cheng1; Niu, Yang1,2; Li, Ke1,2; Zhao, Xi1,2; Liu, Jia-Jia1 | |
| 刊名 | Cell research
 |
| 2009-12-01 | |
| 卷号 | 19期号:12页码:1334-1349 |
| 关键词 | Sorting nexin Retromer P150(glued) Retrograde transport Dynein/dynactin Ci-mpr |
| ISSN号 | 1001-0602 |
| DOI | 10.1038/cr.2009.130 |
| 通讯作者 | Liu, jia-jia(jjliu@genetics.ac.cn) |
| 英文摘要 | The retromer is a protein complex that mediates retrograde transport of transmembrane cargoes from endosomes to the trans-golgi network (tgn). it is comprised of a cargo-selection subcomplex of vps26, vps29 and vps35 and a membrane-binding coat subcomplex of sorting nexins (snxs). previous studies identified snx1/2 as one of the components of the snx subcomplex, and snx5/6 as candidates for the second snx. how the retromer-associated cargoes are recognized and transported by molecular motors are largely unknown. in this study, we found that one of snx1/2's dimerization partners, snx6, interacts with the p150(glued) subunit of the dynein/dynactin motor complex. we present evidence that snx6 is a component of the retromer, and that recruitment of the motor complex to the membrane-associated retromer requires the snx6-p150(glued) interaction. disruption of the snx6-p150glued interaction causes failure in formation and detachment of the tubulovesicular sorting structures from endosomes and results in block of ci-mpr retrieval from endosomes to the tgn. these observations indicate that in addition to snx1/2, snx6 in association with the dynein/dynactin complex drives the formation and movement of tubular retrograde intermediates. |
| WOS关键词 | BETA-III-SPECTRIN ; SORTING NEXIN-1 ; MAMMALIAN RETROMER ; PX-DOMAIN ; COMPLEX ; RECEPTOR ; SUBUNIT ; MOTOR ; MICROTUBULES ; ASSOCIATION |
| WOS研究方向 | Cell Biology |
| WOS类目 | Cell Biology |
| 语种 | 英语 |
| 出版者 | INST BIOCHEMISTRY & CELL BIOLOGY |
| WOS记录号 | WOS:000273785100006 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2403580 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Liu, Jia-Jia |
| 作者单位 | 1.Chinese Acad Sci, Inst Genet & Dev Biol, Key Lab Mol & Dev Biol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hong, Zhi,Yang, Yanrui,Zhang, Cheng,et al. The retromer component snx6 interacts with dynactin p150(glued) and mediates endosome-to-tgn transport[J]. Cell research,2009,19(12):1334-1349. |
| APA | Hong, Zhi.,Yang, Yanrui.,Zhang, Cheng.,Niu, Yang.,Li, Ke.,...&Liu, Jia-Jia.(2009).The retromer component snx6 interacts with dynactin p150(glued) and mediates endosome-to-tgn transport.Cell research,19(12),1334-1349. |
| MLA | Hong, Zhi,et al."The retromer component snx6 interacts with dynactin p150(glued) and mediates endosome-to-tgn transport".Cell research 19.12(2009):1334-1349. |
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