QQ客服 官方微博 反馈留言

	Differential regulation of mrna stability controls the transient expression of genes encoding drosophila antimicrobial peptide with distinct immune response characteristics
	Wei, Youheng1,2,3; Xiao, Qianghai1,2,3; Zhang, Ting1,2; Mou, Zongchun1,2,3; You, Jia1,2,3; Ma, Wei-Jun1,2
刊名	Nucleic acids research
	2009-10-01
卷号	37期号:19页码:6550-6561
ISSN号	0305-1048
DOI	10.1093/nar/gkp693
通讯作者	Ma, wei-jun(wjma@sibs.ac.cn)
英文摘要	The tight regulation of transiently expressed antimicrobial peptides (amps) with a distinct antimicrobial spectrum and different expression kinetics contributes greatly to the properly regulated immune response for resistance to pathogens and for the maintenance of mutualistic microbiota in drosophila. the important role of differential regulation of amp expression at the posttranscriptional level needs to be elucidated. it was observed that the highly expressed cecropin a1 (ceca1) mrna encoding a broad antimicrobial spectrum amp against both bacteria and fungi decayed more quickly than did the moderately expressed diptericin mrna encoding amp against gram negative bacteria. the mrna stability of amps is differentially regulated and is attributed to the specific interaction between cis-acting are in 30-utr of amp mrna and the rna destabilizing protein transactor tis11 as shown in co-immunoprecipitation of the tis11 rnp complex with ceca1 mrna but not other amp mrna. the p38mapk was further demonstrated to play a crucial role in stabilizing are-bearing mrnas by inhibiting tis11-mediated degradation in lps induced amp expression. this evidence suggests an evolutionarily conserved and functionally important molecular basis for and effective approach to exact control of amp gene expression. these mechanisms thereby orchestrate a well balanced and dynamic antimicrobial spectrum of innate immunity to resist infection and maintain resident microbiota properly.
WOS关键词	AU-RICH ELEMENTS ; KAPPA-B ; BINDING-PROTEINS ; DOWN-REGULATION ; HOST-DEFENSE ; IMD-PATHWAY ; TRISTETRAPROLIN ; INDUCTION ; INFECTION ; KINASE
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
语种	英语
出版者	OXFORD UNIV PRESS
WOS记录号	WOS:000271389900022
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2399309
专题	中国科学院大学
通讯作者	Ma, Wei-Jun
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Key Lab Stem Cell Biol, Shanghai 200025, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Med, Shanghai 200025, Peoples R China 3.Chinese Acad Sci, Grad Sch, Shanghai 200025, Peoples R China
推荐引用方式 GB/T 7714	Wei, Youheng,Xiao, Qianghai,Zhang, Ting,et al. Differential regulation of mrna stability controls the transient expression of genes encoding drosophila antimicrobial peptide with distinct immune response characteristics[J]. Nucleic acids research,2009,37(19):6550-6561.
APA	Wei, Youheng,Xiao, Qianghai,Zhang, Ting,Mou, Zongchun,You, Jia,&Ma, Wei-Jun.(2009).Differential regulation of mrna stability controls the transient expression of genes encoding drosophila antimicrobial peptide with distinct immune response characteristics.Nucleic acids research,37(19),6550-6561.
MLA	Wei, Youheng,et al."Differential regulation of mrna stability controls the transient expression of genes encoding drosophila antimicrobial peptide with distinct immune response characteristics".Nucleic acids research 37.19(2009):6550-6561.

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。