QQ客服 官方微博 反馈留言

	Correlation between ka/ks and ks is related to substitution model and evolutionary lineage
	Li, Jun2; Zhang, Zhang2,3,4; Vang, Soren5,6; Yu, Jun2,3,7; Wong, Gane Ka-Shu1,2,7,8; Wang, Jun2,9,10
刊名	Journal of molecular evolution
	2009-04-01
卷号	68期号:4页码:414-423
关键词	Ka/ks Substitution model Evolutionary lineage related
ISSN号	0022-2844
DOI	10.1007/s00239-009-9222-9
通讯作者	Wong, gane ka-shu(gane@ualberta.ca)
英文摘要	In 2005, wyckoff and coworkers described a surprisingly strong correlation between ka/ks and ks in several data sets using the lpb93 algorithm. this finding indicated the possibility of a paradigm shift in the way selection strength can be measured using the ka/ks ratio. we carried out a calculation of ka and ks using six different algorithms on three cross-species orthologous data sets and found a highly variable correlation among the algorithms and lineages. algorithms based on the gy-hky substitution model exhibit a weaker positive correlation or a stronger negative correlation than those based on the k2p and jc69 substitution model. even if one algorithm shows a positive correlation between ka/ks and ks in a warm-blooded lineage, it may show no correlation in a cold-blooded lineage. this algorithm-related and evolutionary lineage-related correlation indicates the need for great caution in drawing conclusions when using only one ka and ks algorithm in a genomewide analysis of selection strength. our results indicated that currently used algorithms for ka and ks calculations are flawed and need improvements.
WOS关键词	NONSYNONYMOUS NUCLEOTIDE SUBSTITUTIONS ; MITOCHONDRIAL-DNA ; NEUTRAL THEORY ; RATES ; GENES ; LIKELIHOOD ; SEQUENCES ; SELECTION ; NUMBERS ; KA
WOS研究方向	Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
WOS类目	Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000265145500010
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2394545
专题	中国科学院大学
通讯作者	Wong, Gane Ka-Shu
作者单位	1.Univ Alberta, Dept Biol Sci, Edmonton, AB T6G 2E9, Canada 2.Beijing Genom Inst, Shenzhen 518083, Peoples R China 3.Chinese Acad Sci, Beijing Inst Genom, Beijing 100080, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 5.Aarhus Univ Hosp, Res Unit Mol Med, DK-8200 Aarhus N, Denmark 6.Univ Aarhus, Fac Hlth Sci, DK-8200 Aarhus N, Denmark 7.Zhejiang Univ, James D Watson Inst Genome Sci, Hangzhou Genom Inst, Key Lab Genom Bioinformat Zhejiang Prov, Hangzhou 310007, Zhejiang, Peoples R China 8.Univ Alberta, Dept Med, Edmonton, AB T6G 2E9, Canada 9.Univ So Denmark, Dept Biochem & Mol Biol, DK-5230 Odense M, Denmark 10.Univ Aarhus, Inst Human Genet, DK-8000 Aarhus C, Denmark
推荐引用方式 GB/T 7714	Li, Jun,Zhang, Zhang,Vang, Soren,et al. Correlation between ka/ks and ks is related to substitution model and evolutionary lineage[J]. Journal of molecular evolution,2009,68(4):414-423.
APA	Li, Jun,Zhang, Zhang,Vang, Soren,Yu, Jun,Wong, Gane Ka-Shu,&Wang, Jun.(2009).Correlation between ka/ks and ks is related to substitution model and evolutionary lineage.Journal of molecular evolution,68(4),414-423.
MLA	Li, Jun,et al."Correlation between ka/ks and ks is related to substitution model and evolutionary lineage".Journal of molecular evolution 68.4(2009):414-423.

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。